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Biosynthesis of the Novel Macrolide Antibiotic Anthracimycin.
Alt S, Wilkinson B. Alt S, et al. Among authors: wilkinson b. ACS Chem Biol. 2015 Nov 20;10(11):2468-79. doi: 10.1021/acschembio.5b00525. Epub 2015 Sep 8. ACS Chem Biol. 2015. PMID: 26349074
Engineering broader specificity into an antibiotic-producing polyketide synthase.
Marsden AF, Wilkinson B, Cortés J, Dunster NJ, Staunton J, Leadlay PF. Marsden AF, et al. Among authors: wilkinson b. Science. 1998 Jan 9;279(5348):199-202. doi: 10.1126/science.279.5348.199. Science. 1998. PMID: 9422686
Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase.
Wilkinson B, Foster G, Rudd BA, Taylor NL, Blackaby AP, Sidebottom PJ, Cooper DJ, Dawson MJ, Buss AD, Gaisser S, Böhm IU, Rowe CJ, Cortés J, Leadlay PF, Staunton J. Wilkinson B, et al. Chem Biol. 2000 Feb;7(2):111-7. doi: 10.1016/s1074-5521(00)00076-4. Chem Biol. 2000. PMID: 10662692
Thus, the six extension modules of the erythromycin PKS (DEBS) together catalyse the production of the specific heptaketide 6-deoxyerythronolide B. RESULTS: A mutant strain of the erythromycin producer Saccharopolyspora erythraea, which accumulates the aglycone intermediat …
Thus, the six extension modules of the erythromycin PKS (DEBS) together catalyse the production of the specific heptaketide 6-deoxyerythrono …
Combinatorial biosynthesis of polyketides and nonribosomal peptides.
Staunton J, Wilkinson B. Staunton J, et al. Among authors: wilkinson b. Curr Opin Chem Biol. 2001 Apr;5(2):159-64. doi: 10.1016/s1367-5931(00)00185-x. Curr Opin Chem Biol. 2001. PMID: 11282342 Review.
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J. Hojati Z, et al. Among authors: wilkinson b. Chem Biol. 2002 Nov;9(11):1175-87. doi: 10.1016/s1074-5521(02)00252-1. Chem Biol. 2002. PMID: 12445768
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions.
Olano C, Wilkinson B, Sánchez C, Moss SJ, Sheridan R, Math V, Weston AJ, Braña AF, Martin CJ, Oliynyk M, Méndez C, Leadlay PF, Salas JA. Olano C, et al. Among authors: wilkinson b. Chem Biol. 2004 Jan;11(1):87-97. doi: 10.1016/j.chembiol.2003.12.018. Chem Biol. 2004. PMID: 15112998
Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues.
Moss SJ, Carletti I, Olano C, Sheridan RM, Ward M, Math V, Nur-E-Alam M, Braña AF, Zhang MQ, Leadlay PF, Méndez C, Salas JA, Wilkinson B. Moss SJ, et al. Among authors: wilkinson b. Chem Commun (Camb). 2006 Jun 14;(22):2341-3. doi: 10.1039/b602931k. Epub 2006 May 11. Chem Commun (Camb). 2006. PMID: 16733573
Mining and engineering natural-product biosynthetic pathways.
Wilkinson B, Micklefield J. Wilkinson B, et al. Nat Chem Biol. 2007 Jul;3(7):379-86. doi: 10.1038/nchembio.2007.7. Nat Chem Biol. 2007. PMID: 17576425 Review.
Engineered biosynthesis of nonribosomal lipopeptides with modified fatty acid side chains.
Powell A, Borg M, Amir-Heidari B, Neary JM, Thirlway J, Wilkinson B, Smith CP, Micklefield J. Powell A, et al. Among authors: wilkinson b. J Am Chem Soc. 2007 Dec 12;129(49):15182-91. doi: 10.1021/ja074331o. Epub 2007 Nov 17. J Am Chem Soc. 2007. PMID: 18020333
Tyl1a, a TDP-6-deoxy-D-xylo-4-hexulose 3,4-isomerase from Streptomyces fradiae: structure prediction, mutagenesis and solvent isotope incorporation experiments to investigate reaction mechanism.
Tello M, Rejzek M, Wilkinson B, Lawson DM, Field RA. Tello M, et al. Among authors: wilkinson b. Chembiochem. 2008 May 23;9(8):1295-302. doi: 10.1002/cbic.200800021. Chembiochem. 2008. PMID: 18425854
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