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Year Number of Results
1972 1
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1980 1
1982 1
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1999 2
2002 3
2003 2
2004 2
2005 2
2006 2
2007 2
2009 4
2010 7
2011 13
2012 32
2013 18
2014 25
2015 18
2016 3
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2019 7
2020 5
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174 results
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Page 1
The dTAG system for immediate and target-specific protein degradation.
Nabet B, Roberts JM, Buckley DL, Paulk J, Dastjerdi S, Yang A, Leggett AL, Erb MA, Lawlor MA, Souza A, Scott TG, Vittori S, Perry JA, Qi J, Winter GE, Wong KK, Gray NS, Bradner JE. Nabet B, et al. Among authors: leggett al. Nat Chem Biol. 2018 May;14(5):431-441. doi: 10.1038/s41589-018-0021-8. Epub 2018 Mar 26. Nat Chem Biol. 2018. PMID: 29581585 Free PMC article.
Using dTAG, we observe an unexpected superior antiproliferative effect of pan-BET bromodomain degradation over selective BRD4 degradation, characterize immediate effects of KRAS(G12V) loss on proteomic signaling, and demonstrate rapid degradation in vivo. This technology platform …
Using dTAG, we observe an unexpected superior antiproliferative effect of pan-BET bromodomain degradation over selective BRD4 degradation, c …
Discovery of a selective inhibitor of doublecortin like kinase 1.
Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RWS, Sulahian R, Li L, Poulin EJ, Huang L, Koren J, Dieguez-Martinez N, Espinosa S, Zeng Z, Corona CR, Vasta JD, Ohi R, Sim T, Kim ND, Harshbarger W, Lizcano JM, Robers MB, Muthaswamy S, Lin CY, Look AT, Haigis KM, Mancias JD, Wolpin BM, Aguirre AJ, Hahn WC, Westover KD, Gray NS. Ferguson FM, et al. Among authors: leggett al. Nat Chem Biol. 2020 Jun;16(6):635-643. doi: 10.1038/s41589-020-0506-0. Epub 2020 Apr 6. Nat Chem Biol. 2020. PMID: 32251410 Free PMC article.
We demonstrate activity of DCLK1-IN-1 against clinically relevant patient-derived PDAC organoid models and use a combination of RNA-sequencing, proteomics and phosphoproteomics analysis to reveal that DCLK1 inhibition modulates proteins and pathways associated with cell motility …
We demonstrate activity of DCLK1-IN-1 against clinically relevant patient-derived PDAC organoid models and use a combination of RNA-sequenci …
Therapies for Long COVID in non-hospitalised individuals: from symptoms, patient-reported outcomes and immunology to targeted therapies (The TLC Study).
Haroon S, Nirantharakumar K, Hughes SE, Subramanian A, Aiyegbusi OL, Davies EH, Myles P, Williams T, Turner G, Chandan JS, McMullan C, Lord J, Wraith DC, McGee K, Denniston AK, Taverner T, Jackson LJ, Sapey E, Gkoutos G, Gokhale K, Leggett E, Iles C, Frost C, McNamara G, Bamford A, Marshall T, Zemedikun DT, Price G, Marwaha S, Simms-Williams N, Brown K, Walker A, Jones K, Matthews K, Camaradou J, Saint-Cricq M, Kumar S, Alder Y, Stanton DE, Agyen L, Baber M, Blaize H, Calvert M. Haroon S, et al. Among authors: leggett e. BMJ Open. 2022 Apr 26;12(4):e060413. doi: 10.1136/bmjopen-2021-060413. BMJ Open. 2022. PMID: 35473737 Free PMC article.
Data will be collected monthly for 1 year.Statistical clustering methods will be used to identify distinct Long COVID-19 symptom clusters. ...Recommendations will be made using the cumulative evidence in an expert consensus workshop. ...
Data will be collected monthly for 1 year.Statistical clustering methods will be used to identify distinct Long COVID-19 sympt …
Radium dial workers: back to the future.
Martinez NE, Jokisch DW, Dauer LT, Eckerman KF, Goans RE, Brockman JD, Tolmachev SY, Avtandilashvili M, Mumma MT, Boice JD Jr, Leggett RW. Martinez NE, et al. Among authors: leggett rw. Int J Radiat Biol. 2022;98(4):750-768. doi: 10.1080/09553002.2021.1917785. Epub 2021 Apr 26. Int J Radiat Biol. 2022. PMID: 33900890 Review.
Comprehensive dose reconstruction techniques are being applied to estimate organ doses for each worker related to the intake of (226)Ra, (228)Ra, and associated photon exposures. Time dependent dose-response analyses will estimate lifetime risks for specific causes of deat …
Comprehensive dose reconstruction techniques are being applied to estimate organ doses for each worker related to the intake of (226)Ra, (22 …
A world of opportunities with nanopore sequencing.
Leggett RM, Clark MD. Leggett RM, et al. J Exp Bot. 2017 Nov 28;68(20):5419-5429. doi: 10.1093/jxb/erx289. J Exp Bot. 2017. PMID: 28992056 Review.
With the release of the high-throughput GridION X5 and PromethION platforms, the sequencing of large genomes will become more cost efficient, and enable the leveraging of extremely long (>100 kb) reads for resolution of complex genomic structures. ...
With the release of the high-throughput GridION X5 and PromethION platforms, the sequencing of large genomes will become more cost ef …
The biokinetics of ruthenium in the human body.
Leggett RW. Leggett RW. Radiat Prot Dosimetry. 2012 Mar;148(4):389-402. doi: 10.1093/rpd/ncr197. Epub 2011 May 11. Radiat Prot Dosimetry. 2012. PMID: 21561945 Review.
The International Commission on Radiological Protection (ICRP) is updating its biokinetic and dosimetric models for workers and subsequently will revisit its models for members of the public. This paper summarises the biokinetic database for ruthenium and proposes a new bi …
The International Commission on Radiological Protection (ICRP) is updating its biokinetic and dosimetric models for workers and subsequently …
Peutz-Jeghers syndrome: genetic screening.
Leggett BA, Young JP, Barker M. Leggett BA, et al. Expert Rev Anticancer Ther. 2003 Aug;3(4):518-24. doi: 10.1586/14737140.3.4.518. Expert Rev Anticancer Ther. 2003. PMID: 12934663 Review.
Diagnostic and predictive genetic testing is now possible in many families due to identification of causative mutations in the serine/threonine kinase (STK)-11 (also known as the LKB1) gene. Such testing has now entered routine clinical practice and will allow early recogn …
Diagnostic and predictive genetic testing is now possible in many families due to identification of causative mutations in the serine/threon …
Measuring functional connectivity with wearable MEG.
Boto E, Hill RM, Rea M, Holmes N, Seedat ZA, Leggett J, Shah V, Osborne J, Bowtell R, Brookes MJ. Boto E, et al. Among authors: leggett j. Neuroimage. 2021 Apr 15;230:117815. doi: 10.1016/j.neuroimage.2021.117815. Epub 2021 Jan 29. Neuroimage. 2021. PMID: 33524584 Free PMC article.
This is the first demonstration of network connectivity measured using OPM-MEG, and results add weight to the argument that OPMs will ultimately supersede cryogenic sensors for MEG measurement....
This is the first demonstration of network connectivity measured using OPM-MEG, and results add weight to the argument that OPMs will
A new era: endoscopic tissue transplantation.
Leggett CL, Gorospe EC, Lutzke L, Anderson M, Wang KK. Leggett CL, et al. Curr Opin Gastroenterol. 2013 Sep;29(5):495-500. doi: 10.1097/MOG.0b013e328363e3fd. Curr Opin Gastroenterol. 2013. PMID: 23872488 Free PMC article. Review.
The availability of engineered tissue for endoscopic application will increase with advances in cell-culturing techniques....
The availability of engineered tissue for endoscopic application will increase with advances in cell-culturing techniques....
Reference-free SNP detection: dealing with the data deluge.
Leggett RM, MacLean D. Leggett RM, et al. BMC Genomics. 2014;15 Suppl 4(Suppl 4):S10. doi: 10.1186/1471-2164-15-S4-S10. Epub 2014 May 20. BMC Genomics. 2014. PMID: 25056481 Free PMC article. Review.
The modern, efficient data structures these tools use enables researchers with a reference sequence to sample many more individuals with lower computing storage and processing overhead. In this article we will discuss the technologies and tools implementing reference-free …
The modern, efficient data structures these tools use enables researchers with a reference sequence to sample many more individuals with low …
174 results