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Determining a minimal important change in a disease-specific Quality of Life Questionnaire.
Juniper EF, Guyatt GH, Willan A, Griffith LE. Juniper EF, et al. J Clin Epidemiol. 1994 Jan;47(1):81-7. doi: 10.1016/0895-4356(94)90036-1. J Clin Epidemiol. 1994. PMID: 8283197
This study was carried out to determine whether the minimal important difference, in evaluative quality of life instruments which use a 7-point scale, is similar across individual domains and for both improvement and deterioration. ...The changes in quality of life score t …
This study was carried out to determine whether the minimal important difference, in evaluative quality of life instruments which use a
Sample size and power issues in estimating incremental cost-effectiveness ratios from clinical trials data.
Willan AR, O'Brien BJ. Willan AR, et al. Health Econ. 1999 May;8(3):203-11. doi: 10.1002/(sici)1099-1050(199905)8:3<203::aid-hec413>3.0.co;2-7. Health Econ. 1999. PMID: 10348415
It is becoming increasingly more common for a randomized controlled trial of a new therapy to include a prospective economic evaluation. ...As a result, for a given sample size, the cost-effectiveness plane is divided into two regions, separated …
It is becoming increasingly more common for a randomized controlled trial of a new therapy to include a prospective eco …
Home nebulizers in childhood asthma. Parental perceptions and practices.
Ryan CA, Willan AR, Wherrett BA. Ryan CA, et al. Clin Pediatr (Phila). 1988 Sep;27(9):420-4. doi: 10.1177/000992288802700902. Clin Pediatr (Phila). 1988. PMID: 2970909
Seventy five percent of 91 parents of asthmatic children (aged 6 months to 15.4 years) with home nebulizers, responded to a questionnaire that sought to document parental experience with this form of therapy. The most common indications for acquiring a nebulizer wer …
Seventy five percent of 91 parents of asthmatic children (aged 6 months to 15.4 years) with home nebulizers, responded to a questionn …
Maternal and infant predictors of attendance at Neonatal Follow-Up programmes.
Ballantyne M, Stevens B, Guttmann A, Willan AR, Rosenbaum P. Ballantyne M, et al. Child Care Health Dev. 2014 Mar;40(2):250-8. doi: 10.1111/cch.12015. Epub 2013 Jan 7. Child Care Health Dev. 2014. PMID: 23294101 Clinical Trial.
Utilizing Andersen's Behavioural Model of Health Services Use, a prospective two-phase multi-site descriptive cohort study was conducted in three Canadian Neonatal Intensive Care Units (NICU) that refer to two affiliated NFU programmes. ...In Phase 2, attendance at NFU was …
Utilizing Andersen's Behavioural Model of Health Services Use, a prospective two-phase multi-site descriptive cohort study was conduc …
Urinary stress incontinence and other maternal outcomes 2 years after caesarean or vaginal birth for twin pregnancy: a multicentre randomised trial.
Hutton EK, Hannah ME, Willan AR, Ross S, Allen AC, Armson BA, Gafni A, Joseph KS, Mangoff K, Ohlsson A, Sanchez JJ, Asztalos EV, Barrett J; Twin Birth Study Collaborative Group. Hutton EK, et al. BJOG. 2018 Dec;125(13):1682-1690. doi: 10.1111/1471-0528.15407. Epub 2018 Aug 27. BJOG. 2018. PMID: 30007113 Free PMC article. Clinical Trial.
DESIGN: Women between 32(0/7) and 38(6/7) weeks of gestation with a twin pregnancy were randomised to planned caesarean or planned vaginal birth. ...CONCLUSIONS: Among women with a twin pregnancy and no prior history of urinary stress incontinence, a manageme …
DESIGN: Women between 32(0/7) and 38(6/7) weeks of gestation with a twin pregnancy were randomised to planned caesarean or planned va …
Response times follow lognormal or gamma distribution in arthritis patients.
Abrahamyan L, Beyene J, Feng J, Chon Y, Willan AR, Schmeling H, Horneff G, Keystone EC, Feldman BM. Abrahamyan L, et al. J Clin Epidemiol. 2010 Dec;63(12):1363-9. doi: 10.1016/j.jclinepi.2009.11.019. J Clin Epidemiol. 2010. PMID: 20430577 Clinical Trial.
STUDY DESIGN AND SETTING: The study used a secondary data analysis design. Data from the trial of etanercept and methotrexate with radiographic patient outcomes were used to model the response times for etanercept (ETN), methotrexate (MTX), and combined ETN+MTX in patients …
STUDY DESIGN AND SETTING: The study used a secondary data analysis design. Data from the trial of etanercept and methotrexate with ra …
Indirect comparison: relative risk fallacies and odds solution.
Eckermann S, Coory M, Willan AR. Eckermann S, et al. J Clin Epidemiol. 2009 Oct;62(10):1031-6. doi: 10.1016/j.jclinepi.2008.10.013. Epub 2009 Jan 29. J Clin Epidemiol. 2009. PMID: 19179043
STUDY DESIGN AND SETTING: Use of RR is shown to lead to inferential fallacies where, for example, a new therapy is suggested to reduce both mortality and survival risk. ...
STUDY DESIGN AND SETTING: Use of RR is shown to lead to inferential fallacies where, for example, a new therapy is suggested to reduc …
Survival distributions impact the power of randomized placebo-phase design and parallel groups randomized clinical trials.
Abrahamyan L, Li CS, Beyene J, Willan AR, Feldman BM. Abrahamyan L, et al. J Clin Epidemiol. 2011 Mar;64(3):286-92. doi: 10.1016/j.jclinepi.2010.02.021. Epub 2010 Oct 6. J Clin Epidemiol. 2011. PMID: 20926258
In the RPPD, at some point, all subjects receive the experimental therapy, and the exposure to placebo is for only a short fixed period of time. ...The RPPD requires more subjects to achieve a similar power to the parallel groups design....
In the RPPD, at some point, all subjects receive the experimental therapy, and the exposure to placebo is for only a short fixed peri …
Conducting EQ-5D Valuation Studies in Resource-Constrained Countries: The Potential Use of Shrinkage Estimators to Reduce Sample Size.
Chan KKW, Xie F, Willan AR, Pullenayegum EM. Chan KKW, et al. Med Decis Making. 2018 Jan;38(1):26-33. doi: 10.1177/0272989X17725748. Epub 2017 Aug 19. Med Decis Making. 2018. PMID: 28823185
BACKGROUND: Resource-constrained countries have difficulty conducting large EQ-5D valuation studies, which limits their ability to conduct cost-utility analyses using a value set specific to their own population. ...METHODS: We conducted a simulation study (1,000 it …
BACKGROUND: Resource-constrained countries have difficulty conducting large EQ-5D valuation studies, which limits their ability to conduct c …
Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study.
Sears MR, Greene JM, Willan AR, Taylor DR, Flannery EM, Cowan JO, Herbison GP, Poulton R. Sears MR, et al. Lancet. 2002 Sep 21;360(9337):901-7. doi: 10.1016/S0140-6736(02)11025-7. Lancet. 2002. PMID: 12354471
We aimed to assess long-term outcomes of asthma and atopy related to breastfeeding in a New Zealand birth cohort. METHODS: Our cohort consisted of 1037 of 1139 children born in Dunedin, New Zealand, between April, 1972, and March, 1973, and residing in Otago province at ag …
We aimed to assess long-term outcomes of asthma and atopy related to breastfeeding in a New Zealand birth cohort. METHODS: Our cohort …
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