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Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis.
Patton EE, Willems AR, Tyers M. Patton EE, et al. Among authors: willems ar. Trends Genet. 1998 Jun;14(6):236-43. doi: 10.1016/s0168-9525(98)01473-5. Trends Genet. 1998. PMID: 9635407 Review.
SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis.
Willems AR, Goh T, Taylor L, Chernushevich I, Shevchenko A, Tyers M. Willems AR, et al. Philos Trans R Soc Lond B Biol Sci. 1999 Sep 29;354(1389):1533-50. doi: 10.1098/rstb.1999.0497. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10582239 Free PMC article.
One ring to rule a superfamily of E3 ubiquitin ligases.
Tyers M, Willems AR. Tyers M, et al. Among authors: willems ar. Science. 1999 Apr 23;284(5414):601, 603-4. doi: 10.1126/science.284.5414.601. Science. 1999. PMID: 10328744 No abstract available.
Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway.
Willems AR, Lanker S, Patton EE, Craig KL, Nason TF, Mathias N, Kobayashi R, Wittenberg C, Tyers M. Willems AR, et al. Cell. 1996 Aug 9;86(3):453-63. doi: 10.1016/s0092-8674(00)80118-x. Cell. 1996. PMID: 8756727
Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast.
Patton EE, Willems AR, Sa D, Kuras L, Thomas D, Craig KL, Tyers M. Patton EE, et al. Among authors: willems ar. Genes Dev. 1998 Mar 1;12(5):692-705. doi: 10.1101/gad.12.5.692. Genes Dev. 1998. PMID: 9499404 Free PMC article.
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.
Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli D, Mercurio F, Shilton BH, Sicheri F, Tyers M. Tang X, et al. Among authors: willems a. Cell. 2007 Jun 15;129(6):1165-76. doi: 10.1016/j.cell.2007.04.042. Cell. 2007. PMID: 17574027
Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases.
Tang X, Orlicky S, Liu Q, Willems A, Sicheri F, Tyers M. Tang X, et al. Among authors: willems a. Methods Enzymol. 2005;399:433-58. doi: 10.1016/S0076-6879(05)99030-7. Methods Enzymol. 2005. PMID: 16338374
A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin.
Willems AR, Schwab M, Tyers M. Willems AR, et al. Biochim Biophys Acta. 2004 Nov 29;1695(1-3):133-70. doi: 10.1016/j.bbamcr.2004.09.027. Biochim Biophys Acta. 2004. PMID: 15571813 Review.
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.
Pintard L, Willems A, Peter M. Pintard L, et al. Among authors: willems a. EMBO J. 2004 Apr 21;23(8):1681-7. doi: 10.1038/sj.emboj.7600186. Epub 2004 Apr 8. EMBO J. 2004. PMID: 15071497 Free PMC article. Review.
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