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Signal integration via PKR.
Williams BR. Williams BR. Sci STKE. 2001 Jul 3;2001(89):re2. doi: 10.1126/stke.2001.89.re2. Sci STKE. 2001. PMID: 11752661 Review.
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.
Marques JT, Devosse T, Wang D, Zamanian-Daryoush M, Serbinowski P, Hartmann R, Fujita T, Behlke MA, Williams BR. Marques JT, et al. Nat Biotechnol. 2006 May;24(5):559-65. doi: 10.1038/nbt1205. Epub 2006 Apr 30. Nat Biotechnol. 2006. PMID: 16648842
Down-regulation of p53 by double-stranded RNA modulates the antiviral response.
Marques JT, Rebouillat D, Ramana CV, Murakami J, Hill JE, Gudkov A, Silverman RH, Stark GR, Williams BR. Marques JT, et al. J Virol. 2005 Sep;79(17):11105-14. doi: 10.1128/JVI.79.17.11105-11114.2005. J Virol. 2005. PMID: 16103161 Free PMC article.
Biochemical analyses of multiple fractions of PKR purified from Escherichia coli.
Xu Z, Wang D, Lee X, Williams BR. Xu Z, et al. J Interferon Cytokine Res. 2004 Sep;24(9):522-35. doi: 10.1089/jir.2004.24.522. J Interferon Cytokine Res. 2004. PMID: 15450128
Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.
Silva AM, Whitmore M, Xu Z, Jiang Z, Li X, Williams BR. Silva AM, et al. J Biol Chem. 2004 Sep 3;279(36):37670-6. doi: 10.1074/jbc.M406554200. Epub 2004 Jun 30. J Biol Chem. 2004. PMID: 15229216
RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR.
Khabar KS, Siddiqui YM, al-Zoghaibi F, al-Haj L, Dhalla M, Zhou A, Dong B, Whitmore M, Paranjape J, Al-Ahdal MN, Al-Mohanna F, Williams BR, Silverman RH. Khabar KS, et al. J Biol Chem. 2003 May 30;278(22):20124-32. doi: 10.1074/jbc.M208766200. Epub 2003 Feb 11. J Biol Chem. 2003. PMID: 12582177
Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR.
Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X. Jiang Z, et al. J Biol Chem. 2003 May 9;278(19):16713-9. doi: 10.1074/jbc.M300562200. Epub 2003 Feb 27. J Biol Chem. 2003. PMID: 12609980
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