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How cells respond to interferons.

Stark GR, Kerr IM, Williams BR, Silverman RH, Schreiber RD. Stark GR, et al. Among authors: williams br. Annu Rev Biochem. 1998;67:227-64. doi: 10.1146/annurev.biochem.67.1.227. Annu Rev Biochem. 1998. PMID: 9759489 Review.

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Functional annotation of IFN-alpha-stimulated gene expression profiles from sensitive and resistant renal cell carcinoma cell lines.

Holko M, Williams BR. Holko M, et al. Among authors: williams br. J Interferon Cytokine Res. 2006 Aug;26(8):534-47. doi: 10.1089/jir.2006.26.534. J Interferon Cytokine Res. 2006. PMID: 16881864

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The role of PACT in mediating gene induction, PKR activation, and apoptosis in response to diverse stimuli.

Marques JT, White CL, Peters GA, Williams BR, Sen GC. Marques JT, et al. Among authors: williams br. J Interferon Cytokine Res. 2008 Aug;28(8):469-76. doi: 10.1089/jir.2007.0006. J Interferon Cytokine Res. 2008. PMID: 18729737 Free PMC article.

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A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

Marques JT, Devosse T, Wang D, Zamanian-Daryoush M, Serbinowski P, Hartmann R, Fujita T, Behlke MA, Williams BR. Marques JT, et al. Among authors: williams br. Nat Biotechnol. 2006 May;24(5):559-65. doi: 10.1038/nbt1205. Epub 2006 Apr 30. Nat Biotechnol. 2006. PMID: 16648842

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Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.

Silva AM, Whitmore M, Xu Z, Jiang Z, Li X, Williams BR. Silva AM, et al. Among authors: williams br. J Biol Chem. 2004 Sep 3;279(36):37670-6. doi: 10.1074/jbc.M406554200. Epub 2004 Jun 30. J Biol Chem. 2004. PMID: 15229216

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Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR.

Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X. Jiang Z, et al. Among authors: williams br. J Biol Chem. 2003 May 9;278(19):16713-9. doi: 10.1074/jbc.M300562200. Epub 2003 Feb 27. J Biol Chem. 2003. PMID: 12609980

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Viral apoptosis is induced by IRF-3-mediated activation of Bax.

Chattopadhyay S, Marques JT, Yamashita M, Peters KL, Smith K, Desai A, Williams BR, Sen GC. Chattopadhyay S, et al. Among authors: williams br. EMBO J. 2010 May 19;29(10):1762-73. doi: 10.1038/emboj.2010.50. Epub 2010 Apr 1. EMBO J. 2010. PMID: 20360684 Free PMC article.

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Determinants of cytokine induction by small interfering RNA in human peripheral blood mononuclear cells.

Zamanian-Daryoush M, Marques JT, Gantier MP, Behlke MA, John M, Rayman P, Finke J, Williams BR. Zamanian-Daryoush M, et al. Among authors: williams br. J Interferon Cytokine Res. 2008 Apr;28(4):221-33. doi: 10.1089/jir.2007.0090. J Interferon Cytokine Res. 2008. PMID: 18439100

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Negative regulation of TLR-signaling pathways by activating transcription factor-3.

Whitmore MM, Iparraguirre A, Kubelka L, Weninger W, Hai T, Williams BR. Whitmore MM, et al. Among authors: williams br. J Immunol. 2007 Sep 15;179(6):3622-30. doi: 10.4049/jimmunol.179.6.3622. J Immunol. 2007. PMID: 17785797

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A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.

Malathi K, Paranjape JM, Bulanova E, Shim M, Guenther-Johnson JM, Faber PW, Eling TE, Williams BR, Silverman RH. Malathi K, et al. Among authors: williams br. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14533-8. doi: 10.1073/pnas.0507551102. Epub 2005 Oct 3. Proc Natl Acad Sci U S A. 2005. PMID: 16203993 Free PMC article.

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