Williams CD - Search Results

1

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.

McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H. McGill MR, et al. Among authors: williams cd. J Clin Invest. 2012 Apr;122(4):1574-83. doi: 10.1172/JCI59755. Epub 2012 Mar 1. J Clin Invest. 2012. PMID: 22378043 Free PMC article.

2

Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.

Williams CD, Bajt ML, Farhood A, Jaeschke H. Williams CD, et al. Liver Int. 2010 Oct;30(9):1280-92. doi: 10.1111/j.1478-3231.2010.02284.x. Liver Int. 2010. PMID: 20500806 Free PMC article.

3

Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury.

Williams CD, Farhood A, Jaeschke H. Williams CD, et al. Toxicol Appl Pharmacol. 2010 Sep 15;247(3):169-78. doi: 10.1016/j.taap.2010.07.004. Epub 2010 Jul 15. Toxicol Appl Pharmacol. 2010. PMID: 20637792 Free PMC article.

4

Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.

Jaeschke H, McGill MR, Williams CD, Ramachandran A. Jaeschke H, et al. Among authors: williams cd. Life Sci. 2011 Apr 25;88(17-18):737-45. doi: 10.1016/j.lfs.2011.01.025. Epub 2011 Feb 4. Life Sci. 2011. PMID: 21296090 Free PMC article. Review.

5

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity.

Jaeschke H, Williams CD, Ramachandran A, Bajt ML. Jaeschke H, et al. Among authors: williams cd. Liver Int. 2012 Jan;32(1):8-20. doi: 10.1111/j.1478-3231.2011.02501.x. Epub 2011 Mar 14. Liver Int. 2012. PMID: 21745276 Free PMC article. Review.

6

Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.

Williams CD, Koerner MR, Lampe JN, Farhood A, Jaeschke H. Williams CD, et al. Toxicol Appl Pharmacol. 2011 Dec 15;257(3):449-58. doi: 10.1016/j.taap.2011.10.006. Epub 2011 Oct 14. Toxicol Appl Pharmacol. 2011. PMID: 22023962 Free PMC article.

7

Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.

McGill MR, Williams CD, Xie Y, Ramachandran A, Jaeschke H. McGill MR, et al. Among authors: williams cd. Toxicol Appl Pharmacol. 2012 Nov 1;264(3):387-94. doi: 10.1016/j.taap.2012.08.015. Epub 2012 Aug 23. Toxicol Appl Pharmacol. 2012. PMID: 22980195 Free PMC article.

8

Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.

Xie Y, Williams CD, McGill MR, Lebofsky M, Ramachandran A, Jaeschke H. Xie Y, et al. Among authors: williams cd. Toxicol Sci. 2013 Jan;131(1):325-35. doi: 10.1093/toxsci/kfs283. Epub 2012 Sep 17. Toxicol Sci. 2013. PMID: 22986947 Free PMC article.

9

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.

McGill MR, Lebofsky M, Norris HR, Slawson MH, Bajt ML, Xie Y, Williams CD, Wilkins DG, Rollins DE, Jaeschke H. McGill MR, et al. Among authors: williams cd. Toxicol Appl Pharmacol. 2013 Jun 15;269(3):240-9. doi: 10.1016/j.taap.2013.03.026. Epub 2013 Apr 6. Toxicol Appl Pharmacol. 2013. PMID: 23571099 Free PMC article.

10

Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress.

Williams CD, McGill MR, Farhood A, Jaeschke H. Williams CD, et al. Food Chem Toxicol. 2013 Aug;58:228-35. doi: 10.1016/j.fct.2013.04.031. Epub 2013 Apr 27. Food Chem Toxicol. 2013. PMID: 23628456 Free PMC article.

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