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On the evolution of functional secondary metabolites (natural products).
Stone MJ, Williams DH. Stone MJ, et al. Among authors: williams dh. Mol Microbiol. 1992 Jan;6(1):29-34. doi: 10.1111/j.1365-2958.1992.tb00834.x. Mol Microbiol. 1992. PMID: 1738312 Review.
Ligand binding energy and catalytic efficiency from improved packing within receptors and enzymes.
Williams DH, Stephens E, Zhou M. Williams DH, et al. J Mol Biol. 2003 May 30;329(2):389-99. doi: 10.1016/s0022-2836(03)00428-5. J Mol Biol. 2003. PMID: 12758085
Order changes within receptor systems upon ligand binding: receptor tightening/oligomerisation and the interpretation of binding parameters.
Williams DH, O'Brien DP, Sandercock AM, Stephens E. Williams DH, et al. J Mol Biol. 2004 Jul 2;340(2):373-83. doi: 10.1016/j.jmb.2004.04.056. J Mol Biol. 2004. PMID: 15201058
Ligand binding energy and enzyme efficiency from reductions in protein dynamics.
Williams DH, Zhou M, Stephens E. Williams DH, et al. J Mol Biol. 2006 Jan 27;355(4):760-7. doi: 10.1016/j.jmb.2005.11.015. Epub 2005 Nov 22. J Mol Biol. 2006. PMID: 16325850
The Vancomycin Group of Antibiotics and the Fight against Resistant Bacteria.
Williams DH, Bardsley B. Williams DH, et al. Angew Chem Int Ed Engl. 1999 May 3;38(9):1172-1193. doi: 10.1002/(SICI)1521-3773(19990503)38:9<1172::AID-ANIE1172>3.0.CO;2-C. Angew Chem Int Ed Engl. 1999. PMID: 29711719 Review.
Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine.
Lamers MB, Antson AA, Hubbard RE, Scott RK, Williams DH. Lamers MB, et al. Among authors: williams dh. J Mol Biol. 1999 Jan 15;285(2):713-25. doi: 10.1006/jmbi.1998.2369. J Mol Biol. 1999. PMID: 9878439
Binding of glycopeptide antibiotics to a model of a vancomycin-resistant bacterium.
Cooper MA, Williams DH. Cooper MA, et al. Among authors: williams dh. Chem Biol. 1999 Dec;6(12):891-9. doi: 10.1016/s1074-5521(00)80008-3. Chem Biol. 1999. PMID: 10631517
Toward an estimation of binding constants in aqueous solution: studies of associations of vancomycin group antibiotics.
Williams DH, Searle MS, Mackay JP, Gerhard U, Maplestone RA. Williams DH, et al. Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1172-8. doi: 10.1073/pnas.90.4.1172. Proc Natl Acad Sci U S A. 1993. PMID: 8433979 Free PMC article.
Why are secondary metabolites (natural products) biosynthesized?
Williams DH, Stone MJ, Hauck PR, Rahman SK. Williams DH, et al. J Nat Prod. 1989 Nov-Dec;52(6):1189-208. doi: 10.1021/np50066a001. J Nat Prod. 1989. PMID: 2693613 Review.
Why are secondary metabolites biosynthesized? Sophistication in the inhibition of cell wall biosynthesis by vancomycin group antibiotics.
Williams DH, Maplestone RA. Williams DH, et al. Ciba Found Symp. 1992;171:45-59; discussion 59-63. doi: 10.1002/9780470514344.ch4. Ciba Found Symp. 1992. PMID: 1302185 Review.
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