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1,102 results
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Vav1 and PI3K are required for phagocytosis of beta-glucan and subsequent superoxide generation by microglia.
Shah VB, Ozment-Skelton TR, Williams DL, Keshvara L. Shah VB, et al. Among authors: williams dl. Mol Immunol. 2009 May;46(8-9):1845-53. doi: 10.1016/j.molimm.2009.01.014. Epub 2009 Feb 20. Mol Immunol. 2009. PMID: 19232731
The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis.
Rosas M, Liddiard K, Kimberg M, Faro-Trindade I, McDonald JU, Williams DL, Brown GD, Taylor PR. Rosas M, et al. Among authors: williams dl. J Immunol. 2008 Sep 1;181(5):3549-57. doi: 10.4049/jimmunol.181.5.3549. J Immunol. 2008. PMID: 18714028
Beta-glucan activates microglia without inducing cytokine production in Dectin-1-dependent manner.
Shah VB, Huang Y, Keshwara R, Ozment-Skelton T, Williams DL, Keshvara L. Shah VB, et al. Among authors: williams dl. J Immunol. 2008 Mar 1;180(5):2777-85. doi: 10.4049/jimmunol.180.5.2777. J Immunol. 2008. PMID: 18292498
Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.
Dennehy KM, Ferwerda G, Faro-Trindade I, Pyz E, Willment JA, Taylor PR, Kerrigan A, Tsoni SV, Gordon S, Meyer-Wentrup F, Adema GJ, Kullberg BJ, Schweighoffer E, Tybulewicz V, Mora-Montes HM, Gow NA, Williams DL, Netea MG, Brown GD. Dennehy KM, et al. Among authors: williams dl. Eur J Immunol. 2008 Feb;38(2):500-6. doi: 10.1002/eji.200737741. Eur J Immunol. 2008. PMID: 18200499 Free PMC article.
The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells.
Willment JA, Marshall AS, Reid DM, Williams DL, Wong SY, Gordon S, Brown GD. Willment JA, et al. Among authors: williams dl. Eur J Immunol. 2005 May;35(5):1539-47. doi: 10.1002/eji.200425725. Eur J Immunol. 2005. PMID: 15816015
Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages.
Herre J, Marshall AS, Caron E, Edwards AD, Williams DL, Schweighoffer E, Tybulewicz V, Reis e Sousa C, Gordon S, Brown GD. Herre J, et al. Among authors: williams dl. Blood. 2004 Dec 15;104(13):4038-45. doi: 10.1182/blood-2004-03-1140. Epub 2004 Aug 10. Blood. 2004. PMID: 15304394
The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages.
Taylor PR, Brown GD, Herre J, Williams DL, Willment JA, Gordon S. Taylor PR, et al. Among authors: williams dl. J Immunol. 2004 Jan 15;172(2):1157-62. doi: 10.4049/jimmunol.172.2.1157. J Immunol. 2004. PMID: 14707091
Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide.
Willment JA, Lin HH, Reid DM, Taylor PR, Williams DL, Wong SY, Gordon S, Brown GD. Willment JA, et al. Among authors: williams dl. J Immunol. 2003 Nov 1;171(9):4569-73. doi: 10.4049/jimmunol.171.9.4569. J Immunol. 2003. PMID: 14568930
Dectin-1 is a major beta-glucan receptor on macrophages.
Brown GD, Taylor PR, Reid DM, Willment JA, Williams DL, Martinez-Pomares L, Wong SY, Gordon S. Brown GD, et al. Among authors: williams dl. J Exp Med. 2002 Aug 5;196(3):407-12. doi: 10.1084/jem.20020470. J Exp Med. 2002. PMID: 12163569 Free PMC article.
Internalization of Dectin-1 terminates induction of inflammatory responses.
Hernanz-Falcón P, Joffre O, Williams DL, Reis e Sousa C. Hernanz-Falcón P, et al. Among authors: williams dl. Eur J Immunol. 2009 Feb;39(2):507-13. doi: 10.1002/eji.200838687. Eur J Immunol. 2009. PMID: 19130473 Free PMC article.
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