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Culture of primary ciliary dyskinesia epithelial cells at air-liquid interface can alter ciliary phenotype but remains a robust and informative diagnostic aid.
Hirst RA, Jackson CL, Coles JL, Williams G, Rutman A, Goggin PM, Adam EC, Page A, Evans HJ, Lackie PM, O'Callaghan C, Lucas JS. Hirst RA, et al. PLoS One. 2014 Feb 25;9(2):e89675. doi: 10.1371/journal.pone.0089675. eCollection 2014. PLoS One. 2014. PMID: 24586956 Free PMC article.
ciliaFA: a research tool for automated, high-throughput measurement of ciliary beat frequency using freely available software.
Smith CM, Djakow J, Free RC, Djakow P, Lonnen R, Williams G, Pohunek P, Hirst RA, Easton AJ, Andrew PW, O'Callaghan C. Smith CM, et al. Cilia. 2012 Aug 1;1:14. doi: 10.1186/2046-2530-1-14. eCollection 2012. Cilia. 2012. PMID: 23351276 Free PMC article.
Ciliary dyskinesia is an early feature of respiratory syncytial virus infection.
Smith CM, Kulkarni H, Radhakrishnan P, Rutman A, Bankart MJ, Williams G, Hirst RA, Easton AJ, Andrew PW, O'Callaghan C. Smith CM, et al. Eur Respir J. 2014 Feb;43(2):485-96. doi: 10.1183/09031936.00205312. Epub 2013 Mar 21. Eur Respir J. 2014. PMID: 23520320
Ciliated cultures from patients with primary ciliary dyskinesia do not produce nitric oxide or inducible nitric oxide synthase during early infection.
Smith CM, Fadaee-Shohada MJ, Sawhney R, Baker N, Williams G, Hirst RA, Andrew PW, O'Callaghan C. Smith CM, et al. Chest. 2013 Nov;144(5):1671-1676. doi: 10.1378/chest.13-0159. Chest. 2013. PMID: 24189859
Severe asthma: Differential chemokine response of airway epithelial cells.
Thomas B, Hirst RA, Brett-Pitt MH, Williams G, Andrew PW, Sousa AR, Marshall RP, Brightling C, O'Callaghan C. Thomas B, et al. J Allergy Clin Immunol. 2017 Oct;140(4):1149-1152.e10. doi: 10.1016/j.jaci.2017.02.040. Epub 2017 Apr 12. J Allergy Clin Immunol. 2017. PMID: 28412395 No abstract available.
Synthetic biology enabling access to designer polyketides.
Malico AA, Nichols L, Williams GJ. Malico AA, et al. Among authors: williams gj. Curr Opin Chem Biol. 2020 Aug 3;58:45-53. doi: 10.1016/j.cbpa.2020.06.003. Online ahead of print. Curr Opin Chem Biol. 2020. PMID: 32758909 Review.
Interplay Between Statins, Cav1 (Caveolin-1), and Aldosterone.
Haas AV, Baudrand R, Easly RM, Murray GR, Touyz RM, Pojoga LH, Jeunemaitre X, Hopkins PN, Rosner B, Williams JS, Williams GH, Adler GK. Haas AV, et al. Among authors: williams gh. Hypertension. 2020 Aug 3:HYPERTENSIONAHA12014777. doi: 10.1161/HYPERTENSIONAHA.120.14777. Online ahead of print. Hypertension. 2020. PMID: 32755411
Impact of body composition on outcomes from anti-PD1 +/- anti-CTLA-4 treatment in melanoma.
Young AC, Quach HT, Song H, Davis EJ, Moslehi JJ, Ye F, Williams GR, Johnson DB. Young AC, et al. Among authors: williams gr. J Immunother Cancer. 2020 Jul;8(2):e000821. doi: 10.1136/jitc-2020-000821. J Immunother Cancer. 2020. PMID: 32747470
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