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Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ. Kidani Y, et al. Among authors: williams kj. Nat Immunol. 2013 May;14(5):489-99. doi: 10.1038/ni.2570. Epub 2013 Apr 7. Nat Immunol. 2013. PMID: 23563690 Free PMC article.
Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum.
Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis AJ, Iruela-Arispe ML, Bostrom KI, Tontonoz P, Reddy ST, Fogelman AM. Mukherjee P, et al. J Lipid Res. 2017 Aug;58(8):1636-1647. doi: 10.1194/jlr.M076554. Epub 2017 Jun 7. J Lipid Res. 2017. PMID: 28592401 Free PMC article.
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins.
Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. Zhou QD, et al. Among authors: williams kj. Nat Immunol. 2020 Jul;21(7):746-755. doi: 10.1038/s41590-020-0695-4. Epub 2020 Jun 8. Nat Immunol. 2020. PMID: 32514064 Free PMC article.
Transcriptional regulation of N6-methyladenosine orchestrates sex-dimorphic metabolic traits.
Salisbury DA, Casero D, Zhang Z, Wang D, Kim J, Wu X, Vergnes L, Mirza AH, Leon-Mimila P, Williams KJ, Huertas-Vazquez A, Jaffrey SR, Reue K, Chen J, Sallam T. Salisbury DA, et al. Among authors: williams kj. Nat Metab. 2021 Jul;3(7):940-953. doi: 10.1038/s42255-021-00427-2. Epub 2021 Jul 19. Nat Metab. 2021. PMID: 34282353 Free PMC article.
Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico.
Flores YN, Amoon AT, Su B, Velazquez-Cruz R, Ramírez-Palacios P, Salmerón J, Rivera-Paredez B, Sinsheimer JS, Lusis AJ, Huertas-Vazquez A, Saab S, Glenn BA, May FP, Williams KJ, Bastani R, Bensinger SJ. Flores YN, et al. Among authors: williams kj. Lipids Health Dis. 2021 Oct 10;20(1):136. doi: 10.1186/s12944-021-01526-5. Lipids Health Dis. 2021. PMID: 34629052 Free PMC article.
IL-10 constrains sphingolipid metabolism to limit inflammation.
York AG, Skadow MH, Oh J, Qu R, Zhou QD, Hsieh WY, Mowel WK, Brewer JR, Kaffe E, Williams KJ, Kluger Y, Smale ST, Crawford JM, Bensinger SJ, Flavell RA. York AG, et al. Among authors: williams kj. Nature. 2024 Mar;627(8004):628-635. doi: 10.1038/s41586-024-07098-5. Epub 2024 Feb 21. Nature. 2024. PMID: 38383790 Free PMC article.
Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.
York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. York AG, et al. Among authors: williams kj. Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10. Cell. 2015. PMID: 26686653 Free PMC article.
625 results