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The role of molecules that mediate apoptosis in T-cell selection.
Williams O, Brady HJ. Williams O, et al. Trends Immunol. 2001 Feb;22(2):107-11. doi: 10.1016/s1471-4906(00)01797-x. Trends Immunol. 2001. PMID: 11286713 Review.
Signaling in primary thymocytes after presentation of altered peptide ligands by antigen-presenting cells or MHC-peptide tetramers.
Smyth LA, Reynolds L, Tyrrell R, Williams O, Norton T, Schumacher T, Tybulewicz V, Ley SC, Kioussis D. Smyth LA, et al. Cold Spring Harb Symp Quant Biol. 1999;64:275-81. doi: 10.1101/sqb.1999.64.275. Cold Spring Harb Symp Quant Biol. 1999. PMID: 11232297 No abstract available.
Elevated Bcl-2 is not a causal event in the positive selection of T cells.
Williams O, Mok CL, Norton T, Harker N, Kioussis D, Brady HJ. Williams O, et al. Eur J Immunol. 2001 Jun;31(6):1876-82. doi: 10.1002/1521-4141(200106)31:6<1876::aid-immu1876>3.0.co;2-f. Eur J Immunol. 2001. PMID: 11433384
Activation of Cdk2 is a requirement for antigen-mediated thymic negative selection.
Williams O, Gil-Gómez G, Norton T, Kioussis D, Brady HJ. Williams O, et al. Eur J Immunol. 2000 Feb;30(2):709-13. doi: 10.1002/1521-4141(200002)30:2<709::AID-IMMU709>3.0.CO;2-9. Eur J Immunol. 2000. PMID: 10671231
Bad can act as a key regulator of T cell apoptosis and T cell development.
Mok CL, Gil-Gómez G, Williams O, Coles M, Taga S, Tolaini M, Norton T, Kioussis D, Brady HJ. Mok CL, et al. J Exp Med. 1999 Feb 1;189(3):575-86. doi: 10.1084/jem.189.3.575. J Exp Med. 1999. PMID: 9927519 Free PMC article.
The action of Bax and bcl-2 on T cell selection.
Williams O, Norton T, Halligey M, Kioussis D, Brady HJ. Williams O, et al. J Exp Med. 1998 Sep 21;188(6):1125-33. doi: 10.1084/jem.188.6.1125. J Exp Med. 1998. PMID: 9743531 Free PMC article.
Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes.
Smyth LA, Williams O, Huby RD, Norton T, Acuto O, Ley SC, Kioussis D. Smyth LA, et al. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8193-8. doi: 10.1073/pnas.95.14.8193. Proc Natl Acad Sci U S A. 1998. PMID: 9653163 Free PMC article.
The intracellular signals induced in thymocytes by such peptides after TCR ligation was examined in CD4(+)8(+) double-positive thymocytes from F5/beta2mo/Rag-1(o) transgenic mice. ...
The intracellular signals induced in thymocytes by such peptides after TCR ligation was examined in CD4(+)8(+) double-positive thymocytes fr …
The agonist-antagonist balance in positive selection.
Williams O, Tanaka Y, Tarazona R, Kioussis D. Williams O, et al. Immunol Today. 1997 Mar;18(3):121-6. doi: 10.1016/s0167-5699(97)01029-3. Immunol Today. 1997. PMID: 9078684 Review.
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