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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1794 1
1845 1
1850 1
1853 1
1888 1
1889 1
1891 2
1892 1
1893 5
1895 1
1896 2
1897 1
1899 6
1900 1
1901 2
1902 2
1903 2
1904 1
1905 1
1906 1
1907 3
1908 8
1909 3
1910 6
1924 2
1932 1
1933 1
1936 2
1937 2
1939 3
1941 1
1945 4
1946 5
1947 4
1948 5
1949 1
1950 5
1951 4
1952 3
1953 8
1954 5
1955 5
1956 6
1957 8
1958 5
1959 8
1960 7
1961 14
1962 10
1963 15
1964 8
1965 8
1966 11
1967 19
1968 14
1969 24
1970 19
1971 36
1972 23
1973 22
1974 32
1975 27
1976 39
1977 23
1978 38
1979 47
1980 51
1981 61
1982 65
1983 69
1984 73
1985 51
1986 75
1987 90
1988 107
1989 101
1990 101
1991 99
1992 90
1993 77
1994 93
1995 94
1996 100
1997 96
1998 89
1999 92
2000 98
2001 120
2002 126
2003 144
2004 125
2005 142
2006 149
2007 137
2008 178
2009 161
2010 173
2011 201
2012 205
2013 215
2014 217
2015 251
2016 224
2017 230
2018 253
2019 235
2020 48
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5,521 results
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Page 1
Goal-directed resuscitation for patients with early septic shock
ARISE Investigators , et al. N Engl J Med 2014 - Clinical Trial. Among authors: Williams P. PMID 25272316 Free article.
Patients in the EGDT group received a larger mean (±SD) volume of intravenous fluids in the first 6 hours after randomization than did those in the usual-care group (1964±1415 ml vs. 1713±1401 ml) and were more likely to receive vasopressor infusions (66.6% vs. 57.8%), red-cell transfusions (13.6% vs. 7.0%), and dobutamine (15.4% vs. 2.6%) (P<0.001 for all comparisons). At 90 days after randomization, 147 deaths had occurred in the EGDT group and 150 had occurred in the usual-care group, for rates of death of 18.6% and 18.8%, respectively (absolute risk difference with EGDT vs. usual care, -0.3 percentage points; 95% confidence interval, -4.1 to 3.6; P=0.90). ...
Patients in the EGDT group received a larger mean (±SD) volume of intravenous fluids in the first 6 hours after randomization than did those …
Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study
Hallberg SJ, et al. Diabetes Ther 2018. Among authors: Williams PT. PMID 29417495 Free PMC article.
Intention-to-treat analysis of the CCI (mean ± SE) revealed HbA(1c) declined from 59.6 ± 1.0 to 45.2 ± 0.8 mmol mol(-1) (7.6 ± 0.09% to 6.3 ± 0.07%, P < 1.0 × 10(-16)), weight declined 13.8 ± 0.71 kg (P < 1.0 × 10(-16)), and T2D medication prescription other than metformin declined from 56.9 ± 3.1% to 29.7 ± 3.0% (P < 1.0 × 10(-16)). ...Additional CCI 1-year effects were HOMA-IR - 55% (P = 3.2 × 10(-5)), hsCRP - 39% (P < 1.0 × 10(-16)), triglycerides - 24% (P < 1.0 × 10(-16)), HDL-cholesterol + 18% (P < 1.0 × 10(-16)), and LDL-cholesterol + 10% (P = 5.1 × 10(-5)); serum creatinine and liver enzymes (ALT, AST, and ALP) declined (P ≤ 0.0001), and apolipoprotein B was unchanged (P = 0.37). ...
Intention-to-treat analysis of the CCI (mean ± SE) revealed HbA(1c) declined from 59.6 ± 1.0 to 45.2 ± 0.8 mmol mol(-1) (7.6 ± 0.09% to 6.3 …
Energy-Dense versus Routine Enteral Nutrition in the Critically Ill
TARGET Investigators, for the ANZICS Clinical Trials Group , et al. N Engl J Med 2018 - Clinical Trial. Among authors: Williams P. PMID 30346225
By day 90, a total of 523 of 1948 patients (26.8%) in the 1.5-kcal group and 505 of 1966 patients (25.7%) in the 1.0-kcal group had died (relative risk, 1.05; 95% CI, 0.94 to 1.16; P=0.41). ...
By day 90, a total of 523 of 1948 patients (26.8%) in the 1.5-kcal group and 505 of 1966 patients (25.7%) in the 1.0-kcal group had died (re …
Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: an open label, non-randomized, controlled study
Bhanpuri NH, et al. Cardiovasc Diabetol 2018 - Clinical Trial. Among authors: Williams PT. PMID 29712560 Free PMC article.
Intention-to-treat analysis (% change) revealed the following at 1-year: total LDL-particles (LDL-P) (- 4.9%, P = 0.02), small LDL-P (- 20.8%, P = 1.2 × 10(-12)), LDL-P size (+ 1.1%, P = 6.0 × 10(-10)), ApoB (- 1.6%, P = 0.37), ApoA1 (+ 9.8%, P < 10(-16)), ApoB/ApoA1 ratio (- 9.5%, P = 1.9 × 10(-7)), triglyceride/HDL-C ratio (- 29.1%, P < 10(-16)), large VLDL-P (- 38.9%, P = 4.2 × 10(-15)), and LDL-C (+ 9.9%, P = 4.9 × 10(-5)). ...The 10-year atherosclerotic cardiovascular disease (ASCVD) risk score decreased - 11.9% (P = 4.9 × 10(-5)). Antihypertensive medication use was discontinued in 11.4% of CCI participants (P = 5.3 × 10(-5)). ...
Intention-to-treat analysis (% change) revealed the following at 1-year: total LDL-particles (LDL-P) (- 4.9%, P = 0.02), small …
Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma
McGeachie MJ, et al. N Engl J Med 2016 - Clinical Trial. Among authors: Williams PV. PMID 27168434 Free PMC article.
Lower baseline values for FEV1, smaller bronchodilator response, airway hyperresponsiveness at baseline, and male sex were associated with reduced growth (P<0.001 for all comparisons). At the last spirometric measurement (mean [±SD] age, 26.0±1.8 years), 73 participants (11%) met Global Initiative for Chronic Obstructive Lung Disease spirometric criteria for lung-function impairment that was consistent with chronic obstructive pulmonary disease (COPD); these participants were more likely to have a reduced pattern of growth than a normal pattern (18% vs. 3%, P<0.001). ...
Lower baseline values for FEV1, smaller bronchodilator response, airway hyperresponsiveness at baseline, and male sex were associated with r …
Cryo-EM in drug discovery
Ceska T, et al. Biochem Soc Trans 2019 - Review. Among authors: Williams PA. PMID 30647139
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