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Characterization of an early afterhyperpolarization after a brief train of action potentials in rat hippocampal neurons in vitro.
Williamson A, Alger BE. Williamson A, et al. J Neurophysiol. 1990 Jan;63(1):72-81. doi: 10.1152/jn.1990.63.1.72. J Neurophysiol. 1990. PMID: 2299387
In rat hippocampal pyramidal cells in vitro, a brief train of action potentials elicited by direct depolarizing current pulses injected through an intracellular recording electrode is followed by a medium-duration afterhyperpolarization (mAHP) and a longer, s …
In rat hippocampal pyramidal cells in vitro, a brief train of action potentials elicited by direct depolarizing current pulses inject …
NPY inhibits glutamatergic excitation in the epileptic human dentate gyrus.
Patrylo PR, van den Pol AN, Spencer DD, Williamson A. Patrylo PR, et al. Among authors: williamson a. J Neurophysiol. 1999 Jul;82(1):478-83. doi: 10.1152/jn.1999.82.1.478. J Neurophysiol. 1999. PMID: 10400974
NPY had a potent and long-lasting inhibitory action on perforant path-evoked excitatory responses. In comparison, the group 3 metabotropic glutamate receptor agonist L-2-amino-4-phosphonobutyric acid (L-AP4) evoked a mild and transient decrease. ...NPY may therefore …
NPY had a potent and long-lasting inhibitory action on perforant path-evoked excitatory responses. In comparison, the group 3 metabot …
Prolonged GABA responses in dentate granule cells in slices isolated from patients with temporal lobe sclerosis.
Williamson A, Telfeian AE, Spencer DD. Williamson A, et al. J Neurophysiol. 1995 Jul;74(1):378-87. doi: 10.1152/jn.1995.74.1.378. J Neurophysiol. 1995. PMID: 7472339
Medial temporal lobe sclerosis is a common pathological finding in patients with medically intractable temporal lobe epilepsy. ...The data support the hypothesis that the GABA transport system is impaired in sclerotic tissue: application of the GABA uptake inhibitor NNC711 …
Medial temporal lobe sclerosis is a common pathological finding in patients with medically intractable temporal lobe epilepsy. ...The …
Relationship between synaptic activity and prolonged field bursts in the dentate gyrus of the rat hippocampal slice.
Schweitzer JS, Williamson A. Schweitzer JS, et al. Among authors: williamson a. J Neurophysiol. 1995 Nov;74(5):1947-52. doi: 10.1152/jn.1995.74.5.1947. J Neurophysiol. 1995. PMID: 8592188
Blockade of N-methyl-D-aspartate (NMDA), non-NMDA, and gamma-aminobutyric acid-A (GABAA)-mediated synaptic transmission during perforant path stimulation resulted in a marked reduction of the ion concentration changes and a loss of both stimulus-evoked and st …
Blockade of N-methyl-D-aspartate (NMDA), non-NMDA, and gamma-aminobutyric acid-A (GABAA)-mediated synaptic transmission during perfor …
A transient calcium-dependent potassium component of the epileptiform burst after-hyperpolarization in rat hippocampus.
Alger BE, Williamson A. Alger BE, et al. Among authors: williamson a. J Physiol. 1988 May;399:191-205. doi: 10.1113/jphysiol.1988.sp017075. J Physiol. 1988. PMID: 3404462 Free PMC article.
We found that phorbol esters indeed blocked the slow components, but also uncovered a transient hyperpolarizing component of the epileptiform burst AHP. ...The transient AHP is Ca2+ dependent: (1) it was often associated with the occurrence of a slow, Ca2+-dependent …
We found that phorbol esters indeed blocked the slow components, but also uncovered a transient hyperpolarizing component of the epil …
A prolonged post-tetanic hyperpolarization in rat hippocampal pyramidal cells in vitro.
Alger BE, Pitler TA, Williamson A. Alger BE, et al. Among authors: williamson a. Brain Res. 1990 Jun 25;521(1-2):118-24. doi: 10.1016/0006-8993(90)91531-k. Brain Res. 1990. PMID: 2169956
In a large proportion of CA1 neurons, stimulation of afferent fibers was followed by a prolonged membrane hyperpolarization (peak amplitude approximately 6 mV) that was associated with a decrease in neuronal input resistance (approximately 33%) that lasted fr …
In a large proportion of CA1 neurons, stimulation of afferent fibers was followed by a prolonged membrane hyperpolarization (p …
Convergence and divergence of neurotransmitter action in human cerebral cortex.
McCormick DA, Williamson A. McCormick DA, et al. Among authors: williamson a. Proc Natl Acad Sci U S A. 1989 Oct;86(20):8098-102. doi: 10.1073/pnas.86.20.8098. Proc Natl Acad Sci U S A. 1989. PMID: 2573061 Free PMC article.
In addition, application of muscarinic receptor agonists to all neurons or of serotonin to middle-layer cells substantially reduced or blocked the M-current (a K+ current that is voltage and time dependent). Inhibition of neuronal firing was elicited by adenosine, baclofen …
In addition, application of muscarinic receptor agonists to all neurons or of serotonin to middle-layer cells substantially reduced or block …
Blockade of GABA synthesis only affects neural excitability under activated conditions in rat hippocampal slices.
Dericioglu N, Garganta CL, Petroff OA, Mendelsohn D, Williamson A. Dericioglu N, et al. Among authors: williamson a. Neurochem Int. 2008 Jul;53(1-2):22-32. doi: 10.1016/j.neuint.2008.04.006. Epub 2008 Apr 22. Neurochem Int. 2008. PMID: 18534717 Free PMC article.
We measured the rate of synthesis of GABA and glutamate in slices using 2-13C-glucose as a label source and liquid chromatography-tandem mass spectrometry. ...Tissue excitability was enhanced following a series of stimulus trains; this effect was enhanced when GABA …
We measured the rate of synthesis of GABA and glutamate in slices using 2-13C-glucose as a label source and liquid chromatography-tan …
Dentate filter function is altered in a proepileptic fashion during aging.
Patrylo PR, Tyagi I, Willingham AL, Lee S, Williamson A. Patrylo PR, et al. Among authors: williamson a. Epilepsia. 2007 Oct;48(10):1964-78. doi: 10.1111/j.1528-1167.2007.01139.x. Epub 2007 May 23. Epilepsia. 2007. PMID: 17521341
Aged rats, compared to adults, exhibit a greater susceptibility to and severity of seizures associated with hippocampal activation. ...
Aged rats, compared to adults, exhibit a greater susceptibility to and severity of seizures associated with hippocampal activation. . …
Gabapentin and vigabatrin increase GABA in the human neocortical slice.
Errante LD, Williamson A, Spencer DD, Petroff OA. Errante LD, et al. Among authors: williamson a. Epilepsy Res. 2002 May;49(3):203-10. doi: 10.1016/s0920-1211(02)00034-7. Epilepsy Res. 2002. PMID: 12076841
These results confirm our MRS studies in vivo that gabapentin increases GABA levels in epileptic patients, but has minimal or no effect in a healthy rodent model. ...
These results confirm our MRS studies in vivo that gabapentin increases GABA levels in epileptic patients, but has minimal or no effect in …
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