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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R. Barnham KJ, et al. Among authors: williamson na. J Biol Chem. 2003 May 9;278(19):17401-7. doi: 10.1074/jbc.M300629200. Epub 2003 Feb 28. J Biol Chem. 2003. PMID: 12611883
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
Barnham KJ, Ciccotosto GD, Tickler AK, Ali FE, Smith DG, Williamson NA, Lam YH, Carrington D, Tew D, Kocak G, Volitakis I, Separovic F, Barrow CJ, Wade JD, Masters CL, Cherny RA, Curtain CC, Bush AI, Cappai R. Barnham KJ, et al. Among authors: williamson na. J Biol Chem. 2003 Oct 31;278(44):42959-65. doi: 10.1074/jbc.M305494200. Epub 2003 Aug 18. J Biol Chem. 2003. PMID: 12925530
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.
Culvenor JG, Ilaya NT, Ryan MT, Canterford L, Hoke DE, Williamson NA, McLean CA, Masters CL, Evin G. Culvenor JG, et al. Among authors: williamson na. Eur J Biochem. 2004 Jan;271(2):375-85. doi: 10.1046/j.1432-1033.2003.03936.x. Eur J Biochem. 2004. PMID: 14717705
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