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A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism.
Kristiansen K, Kroeze WK, Willins DL, Gelber EI, Savage JE, Glennon RA, Roth BL. Kristiansen K, et al. Among authors: willins dl. J Pharmacol Exp Ther. 2000 Jun;293(3):735-46. J Pharmacol Exp Ther. 2000. PMID: 10869371
What's all the RAVE about receptor internalization?
Roth BL, Willins DL. Roth BL, et al. Among authors: willins dl. Neuron. 1999 Aug;23(4):629-31. doi: 10.1016/s0896-6273(02)23443-1. Neuron. 1999. PMID: 10482227 Free article. No abstract available.
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