Willmann S - Search Results

1

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development.

Edginton AN, Theil FP, Schmitt W, Willmann S. Edginton AN, et al. Among authors: willmann s. Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1143-52. doi: 10.1517/17425255.4.9.1143. Expert Opin Drug Metab Toxicol. 2008. PMID: 18721109 Review.

2

Pharmacokinetics, Safety, and Tolerability of Single-Dose Intravenous Moxifloxacin in Pediatric Patients: Dose Optimization in a Phase 1 Study.

Stass H, Lettieri J, Vanevski KM, Willmann S, James LP, Sullivan JE, Arrieta AC, Bradley JS. Stass H, et al. Among authors: willmann s. J Clin Pharmacol. 2019 May;59(5):654-667. doi: 10.1002/jcph.1358. Epub 2019 Jan 25. J Clin Pharmacol. 2019. PMID: 30681729 Clinical Trial.

3

Bodyweight-adjusted rivaroxaban for children with venous thromboembolism (EINSTEIN-Jr): results from three multicentre, single-arm, phase 2 studies.

Monagle P, Lensing AWA, Thelen K, Martinelli I, Male C, Santamaría A, Samochatova E, Kumar R, Holzhauer S, Saracco P, Simioni P, Robertson J, Grangl G, Halton J, Connor P, Young G, Molinari AC, Nowak-Göttl U, Kenet G, Kapsa S, Willmann S, Pap AF, Becka M, Twomey T, Beyer-Westendorf J, Prins MH, Kubitza D; EINSTEIN-Jr Phase 2 Investigators. Monagle P, et al. Among authors: willmann s. Lancet Haematol. 2019 Oct;6(10):e500-e509. doi: 10.1016/S2352-3026(19)30161-9. Epub 2019 Aug 13. Lancet Haematol. 2019. PMID: 31420317 Clinical Trial.

4

Predictive Pediatric Modeling and Simulation Using Ontogeny Information.

Ince I, Solodenko J, Frechen S, Dallmann A, Niederalt C, Schlender J, Burghaus R, Lippert J, Willmann S. Ince I, et al. Among authors: willmann s. J Clin Pharmacol. 2019 Sep;59 Suppl 1:S95-S103. doi: 10.1002/jcph.1497. J Clin Pharmacol. 2019. PMID: 31502689 Review.

5

From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools.

Willmann S, Lippert J, Schmitt W. Willmann S, et al. Expert Opin Drug Metab Toxicol. 2005 Jun;1(1):159-68. doi: 10.1517/17425255.1.1.159. Expert Opin Drug Metab Toxicol. 2005. PMID: 16922658 Review.

6

Development and evaluation of a generic physiologically based pharmacokinetic model for children.

Edginton AN, Schmitt W, Willmann S. Edginton AN, et al. Among authors: willmann s. Clin Pharmacokinet. 2006;45(10):1013-34. doi: 10.2165/00003088-200645100-00005. Clin Pharmacokinet. 2006. PMID: 16984214

7

Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models.

Vossen M, Sevestre M, Niederalt C, Jang IJ, Willmann S, Edginton AN. Vossen M, et al. Among authors: willmann s. Theor Biol Med Model. 2007 Mar 26;4:13. doi: 10.1186/1742-4682-4-13. Theor Biol Med Model. 2007. PMID: 17386084 Free PMC article.

8

Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs.

Willmann S, Höhn K, Edginton A, Sevestre M, Solodenko J, Weiss W, Lippert J, Schmitt W. Willmann S, et al. J Pharmacokinet Pharmacodyn. 2007 Jun;34(3):401-31. doi: 10.1007/s10928-007-9053-5. Epub 2007 Mar 13. J Pharmacokinet Pharmacodyn. 2007. PMID: 17431751

9

Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis.

Edginton AN, Willmann S. Edginton AN, et al. Among authors: willmann s. Clin Pharmacokinet. 2008;47(11):743-52. doi: 10.2165/00003088-200847110-00005. Clin Pharmacokinet. 2008. PMID: 18840029

10

Defining the role of macrophages in local moxifloxacin tissue concentrations using biopsy data and whole-body physiologically based pharmacokinetic modelling.

Edginton AN, Ahr G, Willmann S, Stass H. Edginton AN, et al. Among authors: willmann s. Clin Pharmacokinet. 2009;48(3):181-7. doi: 10.2165/00003088-200948030-00004. Clin Pharmacokinet. 2009. PMID: 19385711

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