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The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation.
Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. Ricote M, et al. Among authors: willson tm. Nature. 1998 Jan 1;391(6662):79-82. doi: 10.1038/34178. Nature. 1998. PMID: 9422508
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).
Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. Lehmann JM, et al. Among authors: willson tm. J Biol Chem. 1995 Jun 2;270(22):12953-6. doi: 10.1074/jbc.270.22.12953. J Biol Chem. 1995. PMID: 7768881
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.
Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. Kliewer SA, et al. Among authors: willson tm. Cell. 1995 Dec 1;83(5):813-9. doi: 10.1016/0092-8674(95)90194-9. Cell. 1995. PMID: 8521498
Discovery of ligands for the nuclear peroxisome proliferator-activated receptors.
Willson TM, Lehmann JM, Kliewer SA. Willson TM, et al. Ann N Y Acad Sci. 1996 Dec 27;804:276-83. doi: 10.1111/j.1749-6632.1996.tb18622.x. Ann N Y Acad Sci. 1996. PMID: 8993550
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.
Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM, Lehmann JM. Kliewer SA, et al. Among authors: willson tm. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4318-23. doi: 10.1073/pnas.94.9.4318. Proc Natl Acad Sci U S A. 1997. PMID: 9113987 Free PMC article.
Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library.
Brown PJ, Smith-Oliver TA, Charifson PS, Tomkinson NC, Fivush AM, Sternbach DD, Wade LE, Orband-Miller L, Parks DJ, Blanchard SG, Kliewer SA, Lehmann JM, Willson TM. Brown PJ, et al. Among authors: willson tm. Chem Biol. 1997 Dec;4(12):909-18. doi: 10.1016/s1074-5521(97)90299-4. Chem Biol. 1997. PMID: 9427656
Peroxisome proliferator-activated receptor agonists.
Willson TM, Wahli W. Willson TM, et al. Curr Opin Chem Biol. 1997 Aug;1(2):235-41. doi: 10.1016/s1367-5931(97)80015-4. Curr Opin Chem Biol. 1997. PMID: 9667857 Review.
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.
Nolte RT, Wisely GB, Westin S, Cobb JE, Lambert MH, Kurokawa R, Rosenfeld MG, Willson TM, Glass CK, Milburn MV. Nolte RT, et al. Among authors: willson tm. Nature. 1998 Sep 10;395(6698):137-43. doi: 10.1038/25931. Nature. 1998. PMID: 9744270
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV. Xu HE, et al. Among authors: willson tm. Mol Cell. 1999 Mar;3(3):397-403. doi: 10.1016/s1097-2765(00)80467-0. Mol Cell. 1999. PMID: 10198642
A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.
Oberfield JL, Collins JL, Holmes CP, Goreham DM, Cooper JP, Cobb JE, Lenhard JM, Hull-Ryde EA, Mohr CP, Blanchard SG, Parks DJ, Moore LB, Lehmann JM, Plunket K, Miller AB, Milburn MV, Kliewer SA, Willson TM. Oberfield JL, et al. Among authors: willson tm. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6102-6. doi: 10.1073/pnas.96.11.6102. Proc Natl Acad Sci U S A. 1999. PMID: 10339548 Free PMC article.
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