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Lyme borreliosis: basic science and clinical aspects.
Pfister HW, Wilske B, Weber K. Pfister HW, et al. Lancet. 1994 Apr 23;343(8904):1013-6. doi: 10.1016/s0140-6736(94)90130-9. Lancet. 1994. PMID: 7909052 Review. No abstract available.
Adhesion of Borrelia garinii to neuronal cells is mediated by the interaction of OspA with proteoglycans.
Rupprecht TA, Koedel U, Heimerl C, Fingerle V, Paul R, Wilske B, Pfister HW. Rupprecht TA, et al. J Neuroimmunol. 2006 Jun;175(1-2):5-11. doi: 10.1016/j.jneuroim.2006.02.007. Epub 2006 Mar 6. J Neuroimmunol. 2006. PMID: 16603253
We demonstrated that (I) OspA-positive B. garinii adhere to neuronal cells, (II) Borrelia adhesion can be blocked by a monoclonal antibody against OspA, (III) preincubation with proteoglycans interferes with the adhesion process and (IV) rOspA directly binds to the proteog …
We demonstrated that (I) OspA-positive B. garinii adhere to neuronal cells, (II) Borrelia adhesion can be blocked by a monoclonal ant …
Diagnosis of lyme borreliosis in europe.
Wilske B. Wilske B. Vector Borne Zoonotic Dis. 2003 Winter;3(4):215-27. doi: 10.1089/153036603322662200. Vector Borne Zoonotic Dis. 2003. PMID: 14733674 Review.
In Europe, Lyme borreliosis is caused by at least three species, B. burgdorferi sensu stricto, B. afzelii and B. garinii. Thus microbiological diagnosis in European patients must consider the heterogeneity of Lyme disease borreliae for development of diagnost …
In Europe, Lyme borreliosis is caused by at least three species, B. burgdorferi sensu stricto, B. afzelii and B. garini …
Dynamics of dissemination and outer surface protein expression of different European Borrelia burgdorferi sensu lato strains in artificially infected Ixodes ricinus nymphs.
Fingerle V, Rauser S, Hammer B, Kahl O, Heimerl C, Schulte-Spechtel U, Gern L, Wilske B. Fingerle V, et al. J Clin Microbiol. 2002 Apr;40(4):1456-63. doi: 10.1128/jcm.40.4.1456-1463.2002. J Clin Microbiol. 2002. PMID: 11923373 Free PMC article.
The OspC-positive B. afzelii clone and all B. garinii OspA type 4 strains were detectable in the salivary glands right after feeding, while one B. garinii OspA type 6 strain invaded the salivary glands with a delay of 24 h. These findings support the hypothes …
The OspC-positive B. afzelii clone and all B. garinii OspA type 4 strains were detectable in the salivary glands right after f …
Epidemiological aspects and molecular characterization of Borrelia burgdorferi s.l. from southern Germany with special respect to the new species Borrelia spielmanii sp. nov.
Fingerle V, Schulte-Spechtel UC, Ruzic-Sabljic E, Leonhard S, Hofmann H, Weber K, Pfister K, Strle F, Wilske B. Fingerle V, et al. Int J Med Microbiol. 2008 Apr;298(3-4):279-90. doi: 10.1016/j.ijmm.2007.05.002. Epub 2007 Jul 5. Int J Med Microbiol. 2008. PMID: 17616434
In 475 Borrelia-infected Ixodes ricinus (2155 ticks investigated) from southern Germany the most common Borrelia burgdorferi sensu lato species was B. garinii (34.3%) followed by B. afzelii (25.1%), B. burgdorferi sensu stricto (22.0%), and B. valaisia …
In 475 Borrelia-infected Ixodes ricinus (2155 ticks investigated) from southern Germany the most common Borrelia burgdorferi sensu lato spec …
Complementation of a Borrelia afzelii OspC mutant highlights the crucial role of OspC for dissemination of Borrelia afzelii in Ixodes ricinus.
Fingerle V, Goettner G, Gern L, Wilske B, Schulte-Spechtel U. Fingerle V, et al. Int J Med Microbiol. 2007 Apr;297(2):97-107. doi: 10.1016/j.ijmm.2006.11.003. Epub 2007 Jan 30. Int J Med Microbiol. 2007. PMID: 17267282
To test the influence of OspC on the dissemination behavior in ticks, unfed Ixodes ricinus nymphs were artificially infected by capillary feeding either with B. afzelii wild type, the B. afzelii ospC mutant or the ospC-complemented clone. ...OspC of B. afzeli …
To test the influence of OspC on the dissemination behavior in ticks, unfed Ixodes ricinus nymphs were artificially infected by capillary fe …
Microbiological and serological diagnosis of Lyme borreliosis.
Wilske B, Fingerle V, Schulte-Spechtel U. Wilske B, et al. FEMS Immunol Med Microbiol. 2007 Feb;49(1):13-21. doi: 10.1111/j.1574-695X.2006.00139.x. FEMS Immunol Med Microbiol. 2007. PMID: 17266710 Review.
In Europe, Lyme borreliosis is caused by Borrelia burgdorferi sensu stricto, B. afzelii, B. garinii and the recently described species B. spielmanii. ...
In Europe, Lyme borreliosis is caused by Borrelia burgdorferi sensu stricto, B. afzelii, B. garinii and the recently described …
Molecular analysis of decorin-binding protein A (DbpA) reveals five major groups among European Borrelia burgdorferi sensu lato strains with impact for the development of serological assays and indicates lateral gene transfer of the dbpA gene.
Schulte-Spechtel U, Fingerle V, Goettner G, Rogge S, Wilske B. Schulte-Spechtel U, et al. Int J Med Microbiol. 2006 May;296 Suppl 40:250-66. doi: 10.1016/j.ijmm.2006.01.006. Epub 2006 Mar 10. Int J Med Microbiol. 2006. PMID: 16530482
Analysis of 25 sequences from the species B. burgdorferi s.s., 16 from B. afzelii, 40 from B. garinii, and two from the recently described human pathogenic genospecies A14S revealed five distinct DbpA groups. Group I comprises B. burgdorferi s.s. and g …
Analysis of 25 sequences from the species B. burgdorferi s.s., 16 from B. afzelii, 40 from B. garinii, and two from the …
Epidemiology and diagnosis of Lyme borreliosis.
Wilske B. Wilske B. Ann Med. 2005;37(8):568-79. doi: 10.1080/07853890500431934. Ann Med. 2005. PMID: 16338759 Review.
In Europe Lyme borreliosis is most frequent in Central Europe and Scandinavia (up to 155 cases per 100,000 individuals) and is caused by the species, B. burgdorferi sensu stricto, B. afzelii and B. garinii. ...
In Europe Lyme borreliosis is most frequent in Central Europe and Scandinavia (up to 155 cases per 100,000 individuals) and is caused by the …
Improvement of Lyme borreliosis serodiagnosis by a newly developed recombinant immunoglobulin G (IgG) and IgM line immunoblot assay and addition of VlsE and DbpA homologues.
Goettner G, Schulte-Spechtel U, Hillermann R, Liegl G, Wilske B, Fingerle V. Goettner G, et al. J Clin Microbiol. 2005 Aug;43(8):3602-9. doi: 10.1128/JCM.43.8.3602-3609.2005. J Clin Microbiol. 2005. PMID: 16081885 Free PMC article.
Heimerl, B. J. Johnson, and B. Wilske, J. Clin. Microbiol. 41:1299-1303, 2003). To verify sensitivity and specificity, both blots were evaluated for reactivity with Borrelia-specific immunoglobulin G (IgG) and IgM antibodies with 85 sera from patients with di …
Heimerl, B. J. Johnson, and B. Wilske, J. Clin. Microbiol. 41:1299-1303, 2003). To verify sensitivity and specificity, …
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