Wilson IA - Search Results

1

Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.

Johnson SM, Connelly S, Wilson IA, Kelly JW. Johnson SM, et al. Among authors: wilson ia. J Med Chem. 2009 Feb 26;52(4):1115-25. doi: 10.1021/jm801347s. J Med Chem. 2009. PMID: 19191553 Free PMC article.

2

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.

Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: wilson ia. Bioorg Med Chem. 2002 Aug;10(8):2739-49. doi: 10.1016/s0968-0896(02)00102-5. Bioorg Med Chem. 2002. PMID: 12057663

3

Structure-based mutagenesis approaches toward expanding the substrate specificity of D-2-deoxyribose-5-phosphate aldolase.

DeSantis G, Liu J, Clark DP, Heine A, Wilson IA, Wong CH. DeSantis G, et al. Among authors: wilson ia. Bioorg Med Chem. 2003 Jan 2;11(1):43-52. doi: 10.1016/s0968-0896(02)00429-7. Bioorg Med Chem. 2003. PMID: 12467706

4

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition.

Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu P, Wormald MR, Stanfield RL, Roux KH, Kelly JW, Rudd PM, Dwek RA, Katinger H, Burton DR, Wilson IA. Calarese DA, et al. Among authors: wilson ia. Science. 2003 Jun 27;300(5628):2065-71. doi: 10.1126/science.1083182. Science. 2003. PMID: 12829775

5

Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.

Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: wilson ia. Bioorg Med Chem. 2003 Oct 1;11(20):4487-501. doi: 10.1016/s0968-0896(03)00456-5. Bioorg Med Chem. 2003. PMID: 13129585

6

10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.

Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: wilson ia. Bioorg Med Chem. 2003 Oct 1;11(20):4503-9. doi: 10.1016/s0968-0896(03)00457-7. Bioorg Med Chem. 2003. PMID: 13129586

7

Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.

Desharnais J, Hwang I, Zhang Y, Tavassoli A, Baboval J, Benkovic SJ, Wilson IA, Boger DL. Desharnais J, et al. Among authors: wilson ia. Bioorg Med Chem. 2003 Oct 1;11(20):4511-21. doi: 10.1016/s0968-0896(03)00458-9. Bioorg Med Chem. 2003. PMID: 13129587

8

Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.

Xu L, Li C, Olson AJ, Wilson IA. Xu L, et al. Among authors: wilson ia. J Biol Chem. 2004 Nov 26;279(48):50555-65. doi: 10.1074/jbc.M406801200. Epub 2004 Sep 7. J Biol Chem. 2004. PMID: 15355974 Free article.

9

Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.

Li C, Xu L, Wolan DW, Wilson IA, Olson AJ. Li C, et al. Among authors: wilson ia. J Med Chem. 2004 Dec 30;47(27):6681-90. doi: 10.1021/jm049504o. J Med Chem. 2004. PMID: 15615517

10

Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis.

Foss TR, Kelker MS, Wiseman RL, Wilson IA, Kelly JW. Foss TR, et al. Among authors: wilson ia. J Mol Biol. 2005 Apr 8;347(4):841-54. doi: 10.1016/j.jmb.2005.01.050. J Mol Biol. 2005. PMID: 15769474

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