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Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers.
Pritchard LK, Vasiljevic S, Ozorowski G, Seabright GE, Cupo A, Ringe R, Kim HJ, Sanders RW, Doores KJ, Burton DR, Wilson IA, Ward AB, Moore JP, Crispin M. Pritchard LK, et al. Cell Rep. 2015 Jun 16;11(10):1604-13. doi: 10.1016/j.celrep.2015.05.017. Epub 2015 Jun 4. Cell Rep. 2015. PMID: 26051934 Free PMC article.
Structure of a V3-containing HIV-1 gp120 core.
Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R, Kwong PD. Huang CC, et al. Science. 2005 Nov 11;310(5750):1025-8. doi: 10.1126/science.1118398. Science. 2005. PMID: 16284180 Free PMC article.
A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Doores KJ, Fulton Z, Hong V, Patel MK, Scanlan CN, Wormald MR, Finn MG, Burton DR, Wilson IA, Davis BG. Doores KJ, et al. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17107-12. doi: 10.1073/pnas.1002717107. Epub 2010 Sep 17. Proc Natl Acad Sci U S A. 2010. PMID: 20852065 Free PMC article.
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures.
Harris A, Borgnia MJ, Shi D, Bartesaghi A, He H, Pejchal R, Kang YK, Depetris R, Marozsan AJ, Sanders RW, Klasse PJ, Milne JL, Wilson IA, Olson WC, Moore JP, Subramaniam S. Harris A, et al. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11440-5. doi: 10.1073/pnas.1101414108. Epub 2011 Jun 27. Proc Natl Acad Sci U S A. 2011. PMID: 21709254 Free PMC article.
Broad neutralization coverage of HIV by multiple highly potent antibodies.
Walker LM, Huber M, Doores KJ, Falkowska E, Pejchal R, Julien JP, Wang SK, Ramos A, Chan-Hui PY, Moyle M, Mitcham JL, Hammond PW, Olsen OA, Phung P, Fling S, Wong CH, Phogat S, Wrin T, Simek MD; Protocol G Principal Investigators, Koff WC, Wilson IA, Burton DR, Poignard P. Walker LM, et al. Nature. 2011 Sep 22;477(7365):466-70. doi: 10.1038/nature10373. Nature. 2011. PMID: 21849977 Free PMC article.
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, Liu Y, McBride R, Ito Y, Sanders RW, Ogohara C, Paulson JC, Feizi T, Scanlan CN, Wong CH, Moore JP, Olson WC, Ward AB, Poignard P, Schief WR, Burton DR, Wilson IA. Pejchal R, et al. Science. 2011 Nov 25;334(6059):1097-103. doi: 10.1126/science.1213256. Epub 2011 Oct 13. Science. 2011. PMID: 21998254 Free PMC article.
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