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Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator.
Ahn GO, Botting KJ, Patterson AV, Ware DC, Tercel M, Wilson WR. Ahn GO, et al. Among authors: wilson wr. Biochem Pharmacol. 2006 Jun 14;71(12):1683-94. doi: 10.1016/j.bcp.2006.03.007. Epub 2006 Mar 14. Biochem Pharmacol. 2006. PMID: 16620789
Previously, we showed that a cobalt(III) complex containing 8-hydroxyquinoline (8-HQ) and cyclen ligands releases 8-HQ efficiently on irradiation in hypoxic solutions [Ahn G-O, Ware DC, Denny WA, Wilson WR. Optimization of the auxiliary ligand shell of cobalt(III)(8 …
Previously, we showed that a cobalt(III) complex containing 8-hydroxyquinoline (8-HQ) and cyclen ligands releases 8-HQ efficiently on irradi …
687 results