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Viral proteinases.
Kräusslich HG, Wimmer E. Kräusslich HG, et al. Annu Rev Biochem. 1988;57:701-54. doi: 10.1146/ Annu Rev Biochem. 1988. PMID: 3052288 Review. No abstract available.
Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization.
Le Nouën C, Brock LG, Luongo C, McCarty T, Yang L, Mehedi M, Wimmer E, Mueller S, Collins PL, Buchholz UJ, DiNapoli JM. Le Nouën C, et al. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13169-74. doi: 10.1073/pnas.1411290111. Epub 2014 Aug 25. Proc Natl Acad Sci U S A. 2014. PMID: 25157129 Free PMC article.
Initiation of protein-primed picornavirus RNA synthesis.
Paul AV, Wimmer E. Paul AV, et al. Virus Res. 2015 Aug 3;206:12-26. doi: 10.1016/j.virusres.2014.12.028. Epub 2015 Jan 12. Virus Res. 2015. PMID: 25592245 Free PMC article. Review.
Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes.
Stauft CB, Shen SH, Song Y, Gorbatsevych O, Asare E, Futcher B, Mueller S, Payne A, Brecher M, Kramer L, Wimmer E. Stauft CB, et al. PLoS One. 2018 Sep 7;13(9):e0198303. doi: 10.1371/journal.pone.0198303. eCollection 2018. PLoS One. 2018. PMID: 30192757 Free PMC article.
Cold-Adapted Viral Attenuation (CAVA): Highly Temperature Sensitive Polioviruses as Novel Vaccine Strains for a Next Generation Inactivated Poliovirus Vaccine.
Sanders BP, de Los Rios Oakes I, van Hoek V, Bockstal V, Kamphuis T, Uil TG, Song Y, Cooper G, Crawt LE, Martín J, Zahn R, Lewis J, Wimmer E, Custers JH, Schuitemaker H, Cello J, Edo-Matas D. Sanders BP, et al. PLoS Pathog. 2016 Mar 31;12(3):e1005483. doi: 10.1371/journal.ppat.1005483. eCollection 2016 Mar. PLoS Pathog. 2016. PMID: 27032093 Free PMC article.
Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets.
Broadbent AJ, Santos CP, Anafu A, Wimmer E, Mueller S, Subbarao K. Broadbent AJ, et al. Vaccine. 2016 Jan 20;34(4):563-570. doi: 10.1016/j.vaccine.2015.11.054. Epub 2015 Dec 2. Vaccine. 2016. PMID: 26655630 Free PMC article.
Binding of glutathione to enterovirus capsids is essential for virion morphogenesis.
Thibaut HJ, van der Linden L, Jiang P, Thys B, Canela MD, Aguado L, Rombaut B, Wimmer E, Paul A, Pérez-Pérez MJ, van Kuppeveld FJ, Neyts J. Thibaut HJ, et al. PLoS Pathog. 2014 Apr 10;10(4):e1004039. doi: 10.1371/journal.ppat.1004039. eCollection 2014 Apr. PLoS Pathog. 2014. PMID: 24722756 Free PMC article.
Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure.
Le Nouën C, McCarty T, Brown M, Smith ML, Lleras R, Dolan MA, Mehedi M, Yang L, Luongo C, Liang B, Munir S, DiNapoli JM, Mueller S, Wimmer E, Collins PL, Buchholz UJ. Le Nouën C, et al. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E386-E395. doi: 10.1073/pnas.1619242114. Epub 2017 Jan 3. Proc Natl Acad Sci U S A. 2017. PMID: 28049853 Free PMC article.
Limits of variation, specific infectivity, and genome packaging of massively recoded poliovirus genomes.
Song Y, Gorbatsevych O, Liu Y, Mugavero J, Shen SH, Ward CB, Asare E, Jiang P, Paul AV, Mueller S, Wimmer E. Song Y, et al. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8731-E8740. doi: 10.1073/pnas.1714385114. Epub 2017 Sep 25. Proc Natl Acad Sci U S A. 2017. PMID: 28973853 Free PMC article.
Computationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector.
Sitaraman V, Hearing P, Ward CB, Gnatenko DV, Wimmer E, Mueller S, Skiena S, Bahou WF. Sitaraman V, et al. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14294-9. doi: 10.1073/pnas.1102883108. Epub 2011 Aug 15. Proc Natl Acad Sci U S A. 2011. PMID: 21844368 Free PMC article.
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