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AZT induces high frequency, rapid amplification of centromeric DNA.
Parra I, Flores C, Adrian D, Windle B. Parra I, et al. Among authors: windle b. Cytogenet Cell Genet. 1997;76(3-4):128-33. doi: 10.1159/000134530. Cytogenet Cell Genet. 1997. PMID: 9186505
The reverse transcriptase inhibitor 3'-azido-deoxythymidine (AZT) has previously been shown to be incorporated into specific regions near the telomeres and centromeres of Chinese hamster ovary cell chromosomes. ...These structures form rapidly within one or two cell cycles …
The reverse transcriptase inhibitor 3'-azido-deoxythymidine (AZT) has previously been shown to be incorporated into specific regions …
Agents that target telomerase and telomeres.
Raymond E, Sun D, Chen SF, Windle B, Von Hoff DD. Raymond E, et al. Among authors: windle b. Curr Opin Biotechnol. 1996 Dec;7(6):583-91. doi: 10.1016/s0958-1669(96)80068-1. Curr Opin Biotechnol. 1996. PMID: 8939642 Review.
Because telomerase is known to be expressed in tumor cells, which concurrently have short telomeres, and not in most somatic cells, which usually have long telomeres, telomerase and telomere structures have been recently proposed as attractive targets for the discovery of …
Because telomerase is known to be expressed in tumor cells, which concurrently have short telomeres, and not in most somatic cells, w …
Preclinical and clinical strategies for development of telomerase and telomere inhibitors.
Sharma S, Raymond E, Soda H, Sun D, Hilsenbeck SG, Sharma A, Izbicka E, Windle B, Von Hoff DD. Sharma S, et al. Among authors: windle b. Ann Oncol. 1997 Nov;8(11):1063-74. doi: 10.1023/a:1008206420505. Ann Oncol. 1997. PMID: 9426325 Review.
We also speculate on the potential toxicities and mechanisms of resistance that may be encountered during use of such therapies....
We also speculate on the potential toxicities and mechanisms of resistance that may be encountered during use of such therapies....
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells.
Izbicka E, Wheelhouse RT, Raymond E, Davidson KK, Lawrence RA, Sun D, Windle BE, Hurley LH, Von Hoff DD. Izbicka E, et al. Among authors: windle be. Cancer Res. 1999 Feb 1;59(3):639-44. Cancer Res. 1999. PMID: 9973212 Free article.
Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.
Von Hoff DD, Needham-VanDevanter DR, Yucel J, Windle BE, Wahl GM. Von Hoff DD, et al. Among authors: windle be. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4804-8. doi: 10.1073/pnas.85.13.4804. Proc Natl Acad Sci U S A. 1988. PMID: 3164477 Free PMC article.
Amplification of genes can sometimes be detected by molecular hybridization but not by cytogenetic methods, suggesting that in some cases the units of amplification may be too small to be detected by light microscopy. ...
Amplification of genes can sometimes be detected by molecular hybridization but not by cytogenetic methods, suggesting that in some c …
High resolution visual mapping of stretched DNA by fluorescent hybridization.
Parra I, Windle B. Parra I, et al. Among authors: windle b. Nat Genet. 1993 Sep;5(1):17-21. doi: 10.1038/ng0993-17. Nat Genet. 1993. PMID: 8106079
Effect of dGTP concentration on human and CHO telomerase.
Maine IP, Chen SF, Windle B. Maine IP, et al. Among authors: windle b. Biochemistry. 1999 Nov 16;38(46):15325-32. doi: 10.1021/bi991596+. Biochemistry. 1999. PMID: 10563818
A simple technique for preparing pure lambda DNA.
Windle BE. Windle BE. Biotechniques. 1988 May;6(5):402, 404, 406-8. Biotechniques. 1988. PMID: 2978838 No abstract available.
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