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A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense.
Wolf D, Anto-Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann JD, Lim B, Bäuml M, Marki A, Mauler M, Duerschmied D, Fan Z, Winkels H, Sidler D, Diehl P, Zajonc DM, Hilgendorf I, Stachon P, Marchini T, Willecke F, Schell M, Sommer B, von Zur Muhlen C, Reinöhl J, Gerhardt T, Plow EF, Yakubenko V, Libby P, Bode C, Ley K, Peter K, Zirlik A. Wolf D, et al. Among authors: winkels h. Nat Commun. 2018 Feb 6;9(1):525. doi: 10.1038/s41467-018-02896-8. Nat Commun. 2018. PMID: 29410422 Free PMC article.
Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.
Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K, Wolf D. Winkels H, et al. Circ Res. 2018 Jun 8;122(12):1675-1688. doi: 10.1161/CIRCRESAHA.117.312513. Epub 2018 Mar 15. Circ Res. 2018. PMID: 29545366 Free PMC article.
A clinically applicable adjuvant for an atherosclerosis vaccine in mice.
Kobiyama K, Vassallo M, Mitzi J, Winkels H, Pei H, Kimura T, Miller J, Wolf D, Ley K. Kobiyama K, et al. Among authors: winkels h. Eur J Immunol. 2018 Sep;48(9):1580-1587. doi: 10.1002/eji.201847584. Epub 2018 Aug 12. Eur J Immunol. 2018. PMID: 29932463 Free PMC article.
Atherosclerosis in the single-cell era.
Winkels H, Ehinger E, Ghosheh Y, Wolf D, Ley K. Winkels H, et al. Curr Opin Lipidol. 2018 Oct;29(5):389-396. doi: 10.1097/MOL.0000000000000537. Curr Opin Lipidol. 2018. PMID: 30020199 Free PMC article. Review.
Migratory and Dancing Macrophage Subsets in Atherosclerotic Lesions.
McArdle S, Buscher K, Ghosheh Y, Pramod AB, Miller J, Winkels H, Wolf D, Ley K. McArdle S, et al. Among authors: winkels h. Circ Res. 2019 Dec 6;125(12):1038-1051. doi: 10.1161/CIRCRESAHA.119.315175. Epub 2019 Oct 9. Circ Res. 2019. PMID: 31594470 Free PMC article.
T cell subsets and functions in atherosclerosis.
Saigusa R, Winkels H, Ley K. Saigusa R, et al. Among authors: winkels h. Nat Rev Cardiol. 2020 Jul;17(7):387-401. doi: 10.1038/s41569-020-0352-5. Epub 2020 Mar 16. Nat Rev Cardiol. 2020. PMID: 32203286 Free PMC article. Review.
Single Cell RNA Sequencing in Atherosclerosis Research.
Williams JW, Winkels H, Durant CP, Zaitsev K, Ghosheh Y, Ley K. Williams JW, et al. Among authors: winkels h. Circ Res. 2020 Apr 24;126(9):1112-1126. doi: 10.1161/CIRCRESAHA.119.315940. Epub 2020 Apr 23. Circ Res. 2020. PMID: 32324494 Free PMC article. Review.
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