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Radioactive 26Al from massive stars in the Galaxy.
Diehl R, Halloin H, Kretschmer K, Lichti GG, Schönfelder V, Strong AW, von Kienlin A, Wang W, Jean P, Knödlseder J, Roques JP, Weidenspointner G, Schanne S, Hartmann DH, Winkler C, Wunderer C. Diehl R, et al. Among authors: Winkler C. Nature. 2006 Jan 5;439(7072):45-7. doi: 10.1038/nature04364. Nature. 2006. PMID: 16397491
We use this to determine that the frequency of core collapse (that is, type Ib/c and type II) supernovae is 1.9 (+/- 1.1) events per century....
We use this to determine that the frequency of core collapse (that is, type Ib/c and type II) supernovae is 1.9 (+/- 1.1) events per …
An asymmetric distribution of positrons in the Galactic disk revealed by gamma-rays.
Weidenspointner G, Skinner G, Jean P, Knödlseder J, von Ballmoos P, Bignami G, Diehl R, Strong AW, Cordier B, Schanne S, Winkler C. Weidenspointner G, et al. Among authors: Winkler C. Nature. 2008 Jan 10;451(7175):159-62. doi: 10.1038/nature06490. Nature. 2008. PMID: 18185581
Compact sources as the origin of the soft gamma-ray emission of the Milky Way.
Lebrun F, Terrier R, Bazzano A, Bélanger G, Bird A, Bouchet L, Dean A, Del Santo M, Goldwurm A, Lund N, Morand H, Parmar A, Paul J, Roques JP, Schönfelder V, Strong AW, Ubertini P, Walter R, Winkler C. Lebrun F, et al. Among authors: Winkler C. Nature. 2004 Mar 18;428(6980):293-6. doi: 10.1038/nature02407. Nature. 2004. PMID: 15029189
Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations.
Steinkellner G, Gruber CC, Pavkov-Keller T, Binter A, Steiner K, Winkler C, Lyskowski A, Schwamberger O, Oberer M, Schwab H, Faber K, Macheroux P, Gruber K. Steinkellner G, et al. Among authors: Winkler C. Nat Commun. 2014 Jun 23;5:4150. doi: 10.1038/ncomms5150. Nat Commun. 2014. PMID: 24954722 Free PMC article.
As a proof-of-concept we identify two enzymes with predicted promiscuous ene-reductase activity (reduction of activated C-C double bonds) and compare them with known ene-reductases, that is, members of the Old Yellow Enzyme family. ...
As a proof-of-concept we identify two enzymes with predicted promiscuous ene-reductase activity (reduction of activated C-C do …
NAD(P)H-independent asymmetric C=C bond reduction catalyzed by ene reductases by using artificial co-substrates as the hydrogen donor.
Winkler CK, Clay D, Entner M, Plank M, Faber K. Winkler CK, et al. Chemistry. 2014 Jan 27;20(5):1403-9. doi: 10.1002/chem.201303897. Epub 2013 Dec 30. Chemistry. 2014. PMID: 24382795 Free PMC article.
To develop a nicotinamide-independent single flavoenzyme system for the asymmetric bioreduction of C=C bonds, four types of hydrogen donor, encompassing more than 50 candidates, were investigated. ...
To develop a nicotinamide-independent single flavoenzyme system for the asymmetric bioreduction of C=C bonds, four types of hy …
A substrate-driven approach to determine reactivities of α,β-unsaturated carboxylic esters towards asymmetric bioreduction.
Tasnádi G, Winkler CK, Clay D, Sultana N, Fabian WM, Hall M, Ditrich K, Faber K. Tasnádi G, et al. Among authors: Winkler CK. Chemistry. 2012 Aug 13;18(33):10362-7. doi: 10.1002/chem.201200990. Epub 2012 Jun 26. Chemistry. 2012. PMID: 22736443
The degree of C=C bond activation in the asymmetric bioreduction of α,β-unsaturated carboxylic esters by ene-reductases was studied, and general recommendations to render these "borderline-substrates" more reactive towards enzymatic reduction are proposed. ...
The degree of C=C bond activation in the asymmetric bioreduction of α,β-unsaturated carboxylic esters by ene-reductases was st …
1,021 results
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