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155 results
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Clinical experience of MEK inhibitors in cancer therapy.
Wang D, Boerner SA, Winkler JD, LoRusso PM. Wang D, et al. Among authors: winkler jd. Biochim Biophys Acta. 2007 Aug;1773(8):1248-55. doi: 10.1016/j.bbamcr.2006.11.009. Epub 2006 Nov 16. Biochim Biophys Acta. 2007. PMID: 17194493 Review.
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor.
Yeh TC, Marsh V, Bernat BA, Ballard J, Colwell H, Evans RJ, Parry J, Smith D, Brandhuber BJ, Gross S, Marlow A, Hurley B, Lyssikatos J, Lee PA, Winkler JD, Koch K, Wallace E. Yeh TC, et al. Among authors: winkler jd. Clin Cancer Res. 2007 Mar 1;13(5):1576-83. doi: 10.1158/1078-0432.CCR-06-1150. Clin Cancer Res. 2007. PMID: 17332304
Pyridinylimidazole inhibitors of Tie2 kinase.
Semones M, Feng Y, Johnson N, Adams JL, Winkler J, Hansbury M. Semones M, et al. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4756-60. doi: 10.1016/j.bmcl.2007.06.068. Epub 2007 Jun 27. Bioorg Med Chem Lett. 2007. PMID: 17618114
Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells.
Chen Z, Clark S, Birkeland M, Sung CM, Lago A, Liu R, Kirkpatrick R, Johanson K, Winkler JD, Hu E. Chen Z, et al. Among authors: winkler jd. Cancer Lett. 2002 Dec 15;188(1-2):127-40. doi: 10.1016/s0304-3835(02)00322-1. Cancer Lett. 2002. PMID: 12406558
Synthesis of and Metal Complexation with a Chiral Cyclam.
Higgins TF, Lee S, Winkler JD. Higgins TF, et al. Among authors: winkler jd. J Org Chem. 2021 Apr 2;86(7):5417-5422. doi: 10.1021/acs.joc.1c00223. Epub 2021 Mar 15. J Org Chem. 2021. PMID: 33720726
SIRT1 is downregulated by autophagy in senescence and ageing.
Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, Bretz C, Winkler JD, Amaravadi R, Garcia BA, Adams PD, Ott M, Tong W, Johansen T, Dou Z, Berger SL. Xu C, et al. Among authors: winkler jd. Nat Cell Biol. 2020 Oct;22(10):1170-1179. doi: 10.1038/s41556-020-00579-5. Epub 2020 Sep 28. Nat Cell Biol. 2020. PMID: 32989246 Free PMC article.
PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma.
Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, Gimotty PA, Xu X, Wherry EJ, Gabrilovich DI, Amaravadi RK. Sharma G, et al. Among authors: winkler jd. JCI Insight. 2020 Sep 3;5(17):e133225. doi: 10.1172/jci.insight.133225. JCI Insight. 2020. PMID: 32780726 Free PMC article.
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