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In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum.
Winzer P, Müller J, Aguado-Martínez A, Rahman M, Balmer V, Manser V, Ortega-Mora LM, Ojo KK, Fan E, Maly DJ, Van Voorhis WC, Hemphill A. Winzer P, et al. Antimicrob Agents Chemother. 2015 Oct;59(10):6361-74. doi: 10.1128/AAC.01236-15. Epub 2015 Jul 27. Antimicrob Agents Chemother. 2015. PMID: 26248379 Free PMC article.
In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts.
Imhof D, Anghel N, Winzer P, Balmer V, Ramseier J, Hänggeli K, Choi R, Hulverson MA, Whitman GR, Arnold SLM, Ojo KK, Van Voorhis WC, Doggett JS, Ortega-Mora LM, Hemphill A. Imhof D, et al. Among authors: winzer p. Int J Parasitol Drugs Drug Resist. 2021 Aug;16:90-101. doi: 10.1016/j.ijpddr.2021.05.001. Epub 2021 May 18. Int J Parasitol Drugs Drug Resist. 2021. PMID: 34030110 Free PMC article.
Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice.
Anghel N, Winzer PA, Imhof D, Müller J, Langa X, Rieder J, Barrett LK, Vidadala RSR, Huang W, Choi R, Hulverson MA, Whitman GR, Arnold SL, Van Voorhis WC, Ojo KK, Maly DJ, Fan E, Hemphill A. Anghel N, et al. Among authors: winzer pa. Int J Antimicrob Agents. 2020 Sep;56(3):106099. doi: 10.1016/j.ijantimicag.2020.106099. Epub 2020 Jul 21. Int J Antimicrob Agents. 2020. PMID: 32707170 Free PMC article.
Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice.
Müller J, Aguado-Martinez A, Manser V, Balmer V, Winzer P, Ritler D, Hostettler I, Arranz-Solís D, Ortega-Mora L, Hemphill A. Müller J, et al. Among authors: winzer p. Int J Parasitol Drugs Drug Resist. 2015 Feb 13;5(1):16-25. doi: 10.1016/j.ijpddr.2015.02.001. eCollection 2015 Apr. Int J Parasitol Drugs Drug Resist. 2015. PMID: 25941626 Free PMC article.
One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases.
Van Voorhis WC, Hulverson MA, Choi R, Huang W, Arnold SLM, Schaefer DA, Betzer DP, Vidadala RSR, Lee S, Whitman GR, Barrett LK, Maly DJ, Riggs MW, Fan E, Kennedy TJ, Tzipori S, Doggett JS, Winzer P, Anghel N, Imhof D, Müller J, Hemphill A, Ferre I, Sanchez-Sanchez R, Ortega-Mora LM, Ojo KK. Van Voorhis WC, et al. Among authors: winzer p. Vet Parasitol. 2021 Jan;289:109336. doi: 10.1016/j.vetpar.2020.109336. Epub 2020 Dec 15. Vet Parasitol. 2021. PMID: 33418437 Free PMC article. Review.
39 results