Wipf P - Search Results

1

Protein kinase D as a potential new target for cancer therapy.

LaValle CR, George KM, Sharlow ER, Lazo JS, Wipf P, Wang QJ. LaValle CR, et al. Among authors: wipf p. Biochim Biophys Acta. 2010 Dec;1806(2):183-92. doi: 10.1016/j.bbcan.2010.05.003. Epub 2010 May 24. Biochim Biophys Acta. 2010. PMID: 20580776 Free PMC article. Review.

2

Synthesis of chemoreversible prodrugs of ara-C with variable time-release profiles. Biological evaluation of their apoptotic activity.

Wipf P, Li W, Adeyeye CM, Rusnak JM, Lazo JS. Wipf P, et al. Bioorg Med Chem. 1996 Oct;4(10):1585-96. doi: 10.1016/0968-0896(96)00153-8. Bioorg Med Chem. 1996. PMID: 8931928

3

Combinatorial synthesis and biological evaluation of library of small-molecule Ser/Thr-protein phosphatase inhibitors.

Wipf P, Cunningham A, Rice RL, Lazo JS. Wipf P, et al. Bioorg Med Chem. 1997 Jan;5(1):165-77. doi: 10.1016/s0968-0896(96)00199-x. Bioorg Med Chem. 1997. PMID: 9043668

4

A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation.

Rice RL, Rusnak JM, Yokokawa F, Yokokawa S, Messner DJ, Boynton AL, Wipf P, Lazo JS. Rice RL, et al. Among authors: wipf p. Biochemistry. 1997 Dec 16;36(50):15965-74. doi: 10.1021/bi971338h. Biochemistry. 1997. PMID: 9398331

5

Disruption of insulin-like growth factor-1 signaling and down-regulation of cdc2 by SC-alphaalphadelta9, a novel small molecule antisignaling agent identified in a targeted array library.

Vogt A, Rice RL, Settineri CE, Yokokawa F, Yokokawa S, Wipf P, Lazo JS. Vogt A, et al. Among authors: wipf p. J Pharmacol Exp Ther. 1998 Nov;287(2):806-13. J Pharmacol Exp Ther. 1998. PMID: 9808713

6

Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor.

Tamura K, Rice RL, Wipf P, Lazo JS. Tamura K, et al. Among authors: wipf p. Oncogene. 1999 Nov 25;18(50):6989-96. doi: 10.1038/sj.onc.1203179. Oncogene. 1999. PMID: 10597298

7

Synthesis and biological evaluation of a targeted library of protein phosphatase inhibitors.

Wipf P, Aslan DC, Luci DK, Southwick EC, Lazo JS. Wipf P, et al. Biotechnol Bioeng. 2000 Winter;71(1):58-70. doi: 10.1002/(sici)1097-0290(200024)71:1<58::aid-bit9>3.0.co;2-0. Biotechnol Bioeng. 2000. PMID: 10629537

8

In vivo antitumor activity and induction of insulin-like growth factor-1-resistant apoptosis by SC-alphaalphadelta9.

Vogt A, Wang AS, Johnson CS, Fabisiak JP, Wipf P, Lazo JS. Vogt A, et al. Among authors: wipf p. J Pharmacol Exp Ther. 2000 Feb;292(2):530-7. J Pharmacol Exp Ther. 2000. PMID: 10640289

9

Combinatorial chemistry and contemporary pharmacology.

Lazo JS, Wipf P. Lazo JS, et al. Among authors: wipf p. J Pharmacol Exp Ther. 2000 Jun;293(3):705-9. doi: 10.1002/chin.200043259. J Pharmacol Exp Ther. 2000. PMID: 10869367

10

Identification of new Cdc25 dual specificity phosphatase inhibitors in a targeted small molecule array.

Ducruet AP, Rice RL, Tamura K, Yokokawa F, Yokokawa S, Wipf P, Lazo JS. Ducruet AP, et al. Among authors: wipf p. Bioorg Med Chem. 2000 Jun;8(6):1451-66. doi: 10.1016/s0968-0896(00)00069-9. Bioorg Med Chem. 2000. PMID: 10896122

.; Yokokawa, F.; Yokokawa, S.; Messner, D. J.; Boynton, A. L.; Wipf, P.; Lazo, J. S. Biochemistry 1997, 36, 15965). Several analogues were identified as effective inhibitors of the protein tyrosine phosphatase (PTPase) PTP1B and the DSPases VHR and Cdc25B2. ...

.; Yokokawa, F.; Yokokawa, S.; Messner, D. J.; Boynton, A. L.; Wipf, P.; Lazo, J. S. Biochemistry 1997, 36, 15965). Several an …

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