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PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine.
Lieberman BP, Ploessl K, Wang L, Qu W, Zha Z, Wise DR, Chodosh LA, Belka G, Thompson CB, Kung HF. Lieberman BP, et al. Among authors: wise dr. J Nucl Med. 2011 Dec;52(12):1947-55. doi: 10.2967/jnumed.111.093815. Epub 2011 Nov 15. J Nucl Med. 2011. PMID: 22095958
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB. Ward PS, et al. Among authors: wise dr. Cancer Cell. 2010 Mar 16;17(3):225-34. doi: 10.1016/j.ccr.2010.01.020. Epub 2010 Feb 18. Cancer Cell. 2010. PMID: 20171147 Free PMC article.
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