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Human PXR forms a tryptophan zipper-mediated homodimer.
Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Noble SM, et al. Among authors: wisely gb. Biochemistry. 2006 Jul 18;45(28):8579-89. doi: 10.1021/bi0602821. Biochemistry. 2006. PMID: 16834332 Free PMC article.
Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene.
Akwabi-Ameyaw A, Caravella JA, Chen L, Creech KL, Deaton DN, Madauss KP, Marr HB, Miller AB, Navas F 3rd, Parks DJ, Spearing PK, Todd D, Williams SP, Wisely GB. Akwabi-Ameyaw A, et al. Among authors: wisely gb. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6154-60. doi: 10.1016/j.bmcl.2011.08.034. Epub 2011 Aug 11. Bioorg Med Chem Lett. 2011. PMID: 21890356
Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.
Bass JY, Caravella JA, Chen L, Creech KL, Deaton DN, Madauss KP, Marr HB, McFadyen RB, Miller AB, Mills WY, Navas F 3rd, Parks DJ, Smalley TL Jr, Spearing PK, Todd D, Williams SP, Wisely GB. Bass JY, et al. Among authors: wisely gb. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1206-13. doi: 10.1016/j.bmcl.2010.12.089. Epub 2010 Dec 23. Bioorg Med Chem Lett. 2011. PMID: 21256005
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