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Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Nat Cancer. 2021 Oct;2(10):1002-1017. Epub 2021 Sep 27.
Nat Cancer. 2021.
PMID: 34790902
Free PMC article.
Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1.
Wiseman AK, Tiedemann RL, Fan H, Shen H, Madaj Z, McCabe MT, Pappalardi MB, Jones PA.
Wiseman AK, et al.
Commun Biol. 2022 Jun 2;5(1):528. doi: 10.1038/s42003-022-03509-3.
Commun Biol. 2022.
PMID: 35654826
Free PMC article.
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Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling.
Chomiak AA, Tiedemann RL, Liu Y, Kong X, Cui Y, Wiseman AK, Thurlow KE, Cornett EM, Topper MJ, Baylin SB, Rothbart SB.
Chomiak AA, et al. Among authors: wiseman ak.
Sci Adv. 2024 Mar 29;10(13):eadk4423. doi: 10.1126/sciadv.adk4423. Epub 2024 Mar 27.
Sci Adv. 2024.
PMID: 38536911
Free PMC article.
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UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation.
Tiedemann RL, Hrit J, Du Q, Wiseman AK, Eden HE, Dickson BM, Kong X, Chomiak AA, Vaughan RM, Hebert JM, David Y, Zhou W, Baylin SB, Jones PA, Clark SJ, Rothbart SB.
Tiedemann RL, et al. Among authors: wiseman ak.
bioRxiv [Preprint]. 2024 Feb 16:2024.02.13.580169. doi: 10.1101/2024.02.13.580169.
bioRxiv. 2024.
PMID: 38405904
Free PMC article.
Preprint.
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DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse.
Zhou W, Hinoue T, Barnes B, Mitchell O, Iqbal W, Lee SM, Foy KK, Lee KH, Moyer EJ, VanderArk A, Koeman JM, Ding W, Kalkat M, Spix NJ, Eagleson B, Pospisilik JA, Szabó PE, Bartolomei MS, Vander Schaaf NA, Kang L, Wiseman AK, Jones PA, Krawczyk CM, Adams M, Porecha R, Chen BH, Shen H, Laird PW.
Zhou W, et al. Among authors: wiseman ak.
Cell Genom. 2022 Jul 13;2(7):100144. doi: 10.1016/j.xgen.2022.100144.
Cell Genom. 2022.
PMID: 35873672
Free PMC article.
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