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Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer.
Paller CJ, Wissing MD, Mendonca J, Sharma A, Kim E, Kim HS, Kortenhorst MS, Gerber S, Rosen M, Shaikh F, Zahurak ML, Rudek MA, Hammers H, Rudin CM, Carducci MA, Kachhap SK. Paller CJ, et al. Among authors: wissing md. Cancer Med. 2014 Oct;3(5):1322-35. doi: 10.1002/cam4.289. Epub 2014 Jul 3. Cancer Med. 2014. PMID: 24989836 Free PMC article.
Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor.
Kachhap SK, Rosmus N, Collis SJ, Kortenhorst MS, Wissing MD, Hedayati M, Shabbeer S, Mendonca J, Deangelis J, Marchionni L, Lin J, Höti N, Nortier JW, DeWeese TL, Hammers H, Carducci MA. Kachhap SK, et al. Among authors: wissing md. PLoS One. 2010 Jun 18;5(6):e11208. doi: 10.1371/journal.pone.0011208. PLoS One. 2010. PMID: 20585447 Free PMC article.
45 results