Withers DJ - Search Results

1

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.

Killick R, Scales G, Leroy K, Causevic M, Hooper C, Irvine EE, Choudhury AI, Drinkwater L, Kerr F, Al-Qassab H, Stephenson J, Yilmaz Z, Giese KP, Brion JP, Withers DJ, Lovestone S. Killick R, et al. Among authors: withers dj. Biochem Biophys Res Commun. 2009 Aug 14;386(1):257-62. doi: 10.1016/j.bbrc.2009.06.032. Epub 2009 Jun 10. Biochem Biophys Res Commun. 2009. PMID: 19523444 Free PMC article.

2

The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ. Choudhury AI, et al. Among authors: withers dj. J Clin Invest. 2005 Apr;115(4):940-50. doi: 10.1172/JCI24445. Epub 2005 Mar 24. J Clin Invest. 2005. PMID: 15841180 Free PMC article.

3

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

Simmgen M, Knauf C, Lopez M, Choudhury AI, Charalambous M, Cantley J, Bedford DC, Claret M, Iglesias MA, Heffron H, Cani PD, Vidal-Puig A, Burcelin R, Withers DJ. Simmgen M, et al. Among authors: withers dj. Diabetologia. 2006 Mar;49(3):552-61. doi: 10.1007/s00125-005-0084-4. Epub 2006 Jan 11. Diabetologia. 2006. PMID: 16404553

4

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances.

Smith MA, Hisadome K, Al-Qassab H, Heffron H, Withers DJ, Ashford ML. Smith MA, et al. Among authors: withers dj. J Physiol. 2007 Jan 15;578(Pt 2):425-38. doi: 10.1113/jphysiol.2006.119479. Epub 2006 Oct 26. J Physiol. 2007. PMID: 17068101 Free PMC article.

5

Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse.

Neganova I, Al-Qassab H, Heffron H, Selman C, Choudhury AI, Lingard SJ, Diakonov I, Patterson M, Ghatei M, Bloom SR, Franks S, Huhtaniemi I, Hardy K, Withers DJ. Neganova I, et al. Among authors: withers dj. Biol Reprod. 2007 Jun;76(6):1045-53. doi: 10.1095/biolreprod.106.059360. Epub 2007 Feb 28. Biol Reprod. 2007. PMID: 17329594

6

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice.

Cantley J, Choudhury AI, Asare-Anane H, Selman C, Lingard S, Heffron H, Herrera P, Persaud SJ, Withers DJ. Cantley J, et al. Among authors: withers dj. Diabetologia. 2007 Jun;50(6):1248-56. doi: 10.1007/s00125-007-0637-9. Epub 2007 Mar 29. Diabetologia. 2007. PMID: 17393136 Free article.

7

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ. Claret M, et al. Among authors: withers dj. J Clin Invest. 2007 Aug;117(8):2325-36. doi: 10.1172/JCI31516. J Clin Invest. 2007. PMID: 17671657 Free PMC article.

8

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.

Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ. Selman C, et al. Among authors: withers dj. FASEB J. 2008 Mar;22(3):807-18. doi: 10.1096/fj.07-9261com. Epub 2007 Oct 10. FASEB J. 2008. PMID: 17928362

9

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis".

Selman C, Lingard S, Gems D, Partridge L, Withers DJ. Selman C, et al. Among authors: withers dj. Science. 2008 May 23;320(5879):1012; author reply 1012. doi: 10.1126/science.1152366. Science. 2008. PMID: 18497277

10

5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus.

Hisadome K, Smith MA, Choudhury AI, Claret M, Withers DJ, Ashford ML. Hisadome K, et al. Among authors: withers dj. Neuroscience. 2009 Mar 3;159(1):83-93. doi: 10.1016/j.neuroscience.2008.12.003. Epub 2008 Dec 14. Neuroscience. 2009. PMID: 19135134 Free PMC article.

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