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Disruption of IRS-2 causes type 2 diabetes in mice.
Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF. Withers DJ, et al. Nature. 1998 Feb 26;391(6670):900-4. doi: 10.1038/36116. Nature. 1998. PMID: 9495343
The role of insulin receptor substrate 2 in hypothalamic and beta cell function.
Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ. Choudhury AI, et al. Among authors: Withers DJ. Version 2. J Clin Invest. 2005 Apr;115(4):940-50. doi: 10.1172/JCI24445. Epub 2005 Mar 24. J Clin Invest. 2005. PMID: 15841180 Free PMC article.
Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse.
Neganova I, Al-Qassab H, Heffron H, Selman C, Choudhury AI, Lingard SJ, Diakonov I, Patterson M, Ghatei M, Bloom SR, Franks S, Huhtaniemi I, Hardy K, Withers DJ. Neganova I, et al. Among authors: Withers DJ. Biol Reprod. 2007 Jun;76(6):1045-53. doi: 10.1095/biolreprod.106.059360. Epub 2007 Feb 28. Biol Reprod. 2007. PMID: 17329594
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ. Selman C, et al. Among authors: Withers DJ. FASEB J. 2008 Mar;22(3):807-18. doi: 10.1096/fj.07-9261com. Epub 2007 Oct 10. FASEB J. 2008. PMID: 17928362
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