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Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling.
Anandanadesan R, Gong Q, Chipitsyna G, Witkiewicz A, Yeo CJ, Arafat HA. Anandanadesan R, et al. J Gastrointest Surg. 2008 Jan;12(1):57-66. doi: 10.1007/s11605-007-0403-9. Epub 2007 Nov 17. J Gastrointest Surg. 2008. PMID: 18026817
AngII-VEGF induction was inhibited by the tyrosine kinase inhibitor genistein, suggesting a mitogen-activated protein kinase signaling mechanism. ...An AT1R-mediated VEGF induction suggests the possibility of AT1R blockade as a novel therapeutic strategy to control …
AngII-VEGF induction was inhibited by the tyrosine kinase inhibitor genistein, suggesting a mitogen-activated protein kinase signalin …
Signal transducer and activator of transcription-3 and breast cancer prognosis.
Sato T, Neilson LM, Peck AR, Liu C, Tran TH, Witkiewicz A, Hyslop T, Nevalainen MT, Sauter G, Rui H. Sato T, et al. Am J Cancer Res. 2011;1(3):347-55. Am J Cancer Res. 2011. PMID: 21776434 Free PMC article.
We therefore retrospectively analyzed the prognostic value of Nuc-pYStat3 in a larger material of 721 breast cancer specimens. ...Levels of Nuc-pYStat3 correlated positively with levels of Nuc-pYStat5, a favorable prognostic marker, in invasive ductal carcinomas. .. …
We therefore retrospectively analyzed the prognostic value of Nuc-pYStat3 in a larger material of 721 breast cancer specimens. ...Lev …
Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?
Showalter SL, Showalter TN, Witkiewicz A, Havens R, Kennedy EP, Hucl T, Kern SE, Yeo CJ, Brody JR. Showalter SL, et al. Cancer Biol Ther. 2008 Jul;7(7):986-94. doi: 10.4161/cbt.7.7.6181. Epub 2008 Apr 21. Cancer Biol Ther. 2008. PMID: 18443433 Free PMC article. Review.
Thymidylate synthase is a target of 5-fluoruracil, a pyrimidine analog used to treat gastrointestinal and other cancers. The 5-fluorouracil metabolite, fluoro-deoxyuridine monophosphate, forms a ternary complex with thymidylate synthase and 5,10-methylene tet …
Thymidylate synthase is a target of 5-fluoruracil, a pyrimidine analog used to treat gastrointestinal and other cancers. The 5 …
The cell fate determination factor dachshund inhibits androgen receptor signaling and prostate cancer cellular growth.
Wu K, Katiyar S, Witkiewicz A, Li A, McCue P, Song LN, Tian L, Jin M, Pestell RG. Wu K, et al. Cancer Res. 2009 Apr 15;69(8):3347-55. doi: 10.1158/0008-5472.CAN-08-3821. Epub 2009 Apr 7. Cancer Res. 2009. PMID: 19351840 Free PMC article.
Initially isolated as the dominant suppressor of the mutant epidermal growth factor receptor (ellipse), the Dachshund gene plays a key role in metazoan development regulating the Retinal Determination Gene Network. ...These studies show a role for the Retinal Determ …
Initially isolated as the dominant suppressor of the mutant epidermal growth factor receptor (ellipse), the Dachshund gene plays a ke …
Gallbladder abnormalities in carcinoma of pancreatic head: findings on MR imaging.
Zhang XM, Mitchell DG, Byun JH, Verma SK, Bergin D, Witkiewicz A. Zhang XM, et al. Abdom Imaging. 2009 Jul;34(4):507-13. doi: 10.1007/s00261-008-9422-6. Abdom Imaging. 2009. PMID: 18546035
Identifying pancreatic cancer patients for targeted treatment: the challenges and limitations of the current selection process and vision for the future.
Showalter SL, Charles S, Belin J, Cozzitorto J, Einstein P, Richards NG, Sauter PK, Kennedy EP, Witkiewicz A, Brody JR, Yeo CJ. Showalter SL, et al. Expert Opin Drug Deliv. 2010 Mar;7(3):273-84. doi: 10.1517/17425240903544462. Expert Opin Drug Deliv. 2010. PMID: 20201734
Patient A developed PDA in the context of a known BRCA2 frameshift mutation (2157delG), suspected because of her personal and multigenerational family history of breast cancer. ...Patient A continues to be disease free 32 months after her diagnosis and treatm …
Patient A developed PDA in the context of a known BRCA2 frameshift mutation (2157delG), suspected because of her personal and …
Induction of monocyte chemoattractant protein-1 by nicotine in pancreatic ductal adenocarcinoma cells: role of osteopontin.
Lazar M, Sullivan J, Chipitsyna G, Aziz T, Salem AF, Gong Q, Witkiewicz A, Denhardt DT, Yeo CJ, Arafat HA. Lazar M, et al. Surgery. 2010 Aug;148(2):298-309. doi: 10.1016/j.surg.2010.05.002. Epub 2010 Jun 25. Surgery. 2010. PMID: 20579680 Free PMC article.
We showed recently that nicotine induces osteopontin (OPN), a protein that plays critical roles in inflammation and tumor metastasis. ...CONCLUSION: Our data suggest that cigarette smoking and nicotine may contribute to PDA inflammation by inducing MCP-1 and provide a
We showed recently that nicotine induces osteopontin (OPN), a protein that plays critical roles in inflammation and tumor metastasis. …
Involvement of osteopontin in the matrix-degrading and proangiogenic changes mediated by nicotine in pancreatic cancer cells.
Lazar M, Sullivan J, Chipitsyna G, Gong Q, Ng CY, Salem AF, Aziz T, Witkiewicz A, Denhardt DT, Yeo CJ, Arafat HA. Lazar M, et al. J Gastrointest Surg. 2010 Oct;14(10):1566-77. doi: 10.1007/s11605-010-1338-0. Epub 2010 Sep 8. J Gastrointest Surg. 2010. PMID: 20824368
Previously, we showed that nicotine promotes the expression of osteopontin c (OPNc), an isoform of OPN protein that confers on cancer cells a migratory phenotype. ...The presence of OPN as a downstream effector of nicotine that is capable of mediating its prometasta …
Previously, we showed that nicotine promotes the expression of osteopontin c (OPNc), an isoform of OPN protein that confers on cancer cells …
Margin positive pancreaticoduodenectomy is superior to palliative bypass in locally advanced pancreatic ductal adenocarcinoma.
Lavu H, Mascaro AA, Grenda DR, Sauter PK, Leiby BE, Croker SP, Witkiewicz A, Berger AC, Rosato EL, Kennedy EP, Yeo CJ. Lavu H, et al. J Gastrointest Surg. 2009 Nov;13(11):1937-46; discussion 1946-7. doi: 10.1007/s11605-009-1000-x. Epub 2009 Sep 16. J Gastrointest Surg. 2009. PMID: 19760308
OBJECTIVE: The aim of this study was to determine if there is a difference in the perioperative outcomes and survival patterns between patients who undergo MP PD and those who undergo PB for locally advanced disease in the treatment of pancreatic ductal adenocarcinoma. ... …
OBJECTIVE: The aim of this study was to determine if there is a difference in the perioperative outcomes and survival patterns betwee …
Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma.
Sullivan J, Blair L, Alnajar A, Aziz T, Ng CY, Chipitsyna G, Gong Q, Witkiewicz A, Weber GF, Denhardt DT, Yeo CJ, Arafat HA. Sullivan J, et al. Surgery. 2009 Aug;146(2):232-40. doi: 10.1016/j.surg.2009.03.036. Surgery. 2009. PMID: 19628079 Free PMC article.
BACKGROUND: Osteopontin (OPN) is a secreted phosphoprotein that confers on cancer cells a migratory phenotype. We demonstrated recently that nicotine, a major risk factor in pancreatic ductal adenocarcinoma (PDA), increases OPN expression in PDA cells. ...Alt …
BACKGROUND: Osteopontin (OPN) is a secreted phosphoprotein that confers on cancer cells a migratory phenotype. We demonstrated …
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