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Rapid-acting antidepressants.
Witkin JM, Martin AE, Golani LK, Xu NZ, Smith JL. Witkin JM, et al. Adv Pharmacol. 2019;86:47-96. doi: 10.1016/bs.apha.2019.03.002. Epub 2019 Apr 24. Adv Pharmacol. 2019. PMID: 31378256 Review.
The Positive Allosteric Modulator of α2/3-Containing GABAA Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury.
Witkin JM, Li G, Golani LK, Xiong W, Smith JL, Ping X, Rashid F, Jahan R, Cerne R, Cook JM, Jin X. Witkin JM, et al. J Pharmacol Exp Ther. 2020 Jan;372(1):83-94. doi: 10.1124/jpet.119.260968. Epub 2019 Nov 6. J Pharmacol Exp Ther. 2020. PMID: 31694876 Free PMC article.
The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance development.
Biggerstaff A, Kivell B, Smith JL, Mian MY, Golani LK, Rashid F, Sharmin D, Knutson DE, Cerne R, Cook JM, Witkin JM. Biggerstaff A, et al. Among authors: witkin jm. Pharmacol Biochem Behav. 2020 Sep;196:172996. doi: 10.1016/j.pbb.2020.172996. Epub 2020 Jul 12. Pharmacol Biochem Behav. 2020. PMID: 32668266
Witkin JM. Witkin JM. Adv Pharmacol. 2019;86:xi-xiii. doi: 10.1016/S1054-3589(19)30059-6. Adv Pharmacol. 2019. PMID: 31378258 No abstract available.
Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3-selective GABAkine KRM-II-81.
Golani LK, Divović B, Sharmin D, Pandey KP, Mian MY, Cerne R, Zahn NM, Meyer MJ, Tiruveedhula VVNPB, Smith JL, Ping X, Jin X, Lippa A, Schkeryantz JM, Arnold LA, Cook JM, Savić MM, Witkin JM. Golani LK, et al. Among authors: witkin jm. Biopharm Drug Dispos. 2022 Apr;43(2):66-75. doi: 10.1002/bdd.2313. Epub 2022 Mar 10. Biopharm Drug Dispos. 2022. PMID: 35194800
The romantic age of pharmacological science.
Witkin JM. Witkin JM. Pharmacol Biochem Behav. 2022 Mar;214:173354. doi: 10.1016/j.pbb.2022.173354. Epub 2022 Feb 14. Pharmacol Biochem Behav. 2022. PMID: 35176349 No abstract available.
236 results