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Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery.
Witthuhn BA, Williams MD, Kerawalla H, Uckun FM. Witthuhn BA, et al. Leuk Lymphoma. 1999 Jan;32(3-4):289-97. doi: 10.3109/10428199909167389. Leuk Lymphoma. 1999. PMID: 10037026
Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis.
Sohn SJ, Forbush KA, Nguyen N, Witthuhn B, Nosaka T, Ihle JN, Perlmutter RM. Sohn SJ, et al. Among authors: witthuhn b. J Immunol. 1998 Mar 1;160(5):2130-8. J Immunol. 1998. PMID: 9498750
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.
Guschin D, Rogers N, Briscoe J, Witthuhn B, Watling D, Horn F, Pellegrini S, Yasukawa K, Heinrich P, Stark GR, et al. Guschin D, et al. Among authors: witthuhn b. EMBO J. 1995 Apr 3;14(7):1421-9. EMBO J. 1995. PMID: 7537214 Free PMC article.
Cytokine receptors and signal transduction.
Ihle JN, Witthuhn B, Tang B, Yi T, Quelle FW. Ihle JN, et al. Among authors: witthuhn b. Baillieres Clin Haematol. 1994 Mar;7(1):17-48. doi: 10.1016/s0950-3536(05)80005-8. Baillieres Clin Haematol. 1994. PMID: 7518712 Review.
Interleukin 4 signals through two related pathways.
Pernis A, Witthuhn B, Keegan AD, Nelms K, Garfein E, Ihle JN, Paul WE, Pierce JH, Rothman P. Pernis A, et al. Among authors: witthuhn b. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7971-5. doi: 10.1073/pnas.92.17.7971. Proc Natl Acad Sci U S A. 1995. PMID: 7544011 Free PMC article.
Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.
Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN, et al. Miyazaki T, et al. Among authors: witthuhn ba. Science. 1994 Nov 11;266(5187):1045-7. doi: 10.1126/science.7973659. Science. 1994. PMID: 7973659
Signaling by the cytokine receptor superfamily: JAKs and STATs.
Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Thierfelder WE, Kreider B, Silvennoinen O. Ihle JN, et al. Among authors: witthuhn ba. Trends Biochem Sci. 1994 May;19(5):222-7. doi: 10.1016/0968-0004(94)90026-4. Trends Biochem Sci. 1994. PMID: 8048164 Review.
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells.
Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, Ihle JN. Witthuhn BA, et al. Nature. 1994 Jul 14;370(6485):153-7. doi: 10.1038/370153a0. Nature. 1994. PMID: 8022486
Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.
Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, Cantrell DA. Beadling C, et al. Among authors: witthuhn ba. EMBO J. 1994 Dec 1;13(23):5605-15. EMBO J. 1994. PMID: 7988557 Free PMC article.
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.
Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O, et al. Russell SM, et al. Among authors: witthuhn ba. Science. 1994 Nov 11;266(5187):1042-5. doi: 10.1126/science.7973658. Science. 1994. PMID: 7973658
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