Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma.
Cancer Cell. 2002.
PMID: 12086864
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Wnt5a signaling directly affected cell motility and invasion or metastatic melanoma
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Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma instead
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PRAME Expression in Melanocytic Tumors.
Am J Surg Pathol. 2018 Nov;42(11):1456-1465. doi: 10.1097/PAS.0000000000001134.
Am J Surg Pathol. 2018.
PMID: 30045064
Free PMC article.
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells in a melanoma patient. ...Diffuse nuclear immunoreactivity for PRAME was found in 87% of metastatic and 83.2% of primary me …
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells …
Metabolic heterogeneity confers differences in melanoma metastatic potential.
Nature. 2020 Jan;577(7788):115-120. doi: 10.1038/s41586-019-1847-2. Epub 2019 Dec 18.
Nature. 2020.
PMID: 31853067
Free PMC article.
Here we show that metabolic differences among melanoma cells confer differences in metastatic potential as a result of differences in the function of the MCT1 transporter. ...MCT1 inhibition had little effect on the growth of primary subcutaneous tumours, but result …
Here we show that metabolic differences among melanoma cells confer differences in metastatic potential as a result of differe …
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.
Nat Genet. 2009 May;41(5):544-52. doi: 10.1038/ng.356. Epub 2009 Mar 12.
Nat Genet. 2009.
PMID: 19282848
Free PMC article.
Melanoma was prevented by inhibitors of mTorc1 (rapamycin) or MEK1/2 (PD325901) but, upon cessation of drug administration, mice developed melanoma, indicating the presence of long-lived melanoma-initiating cells in this system. Notably, combined treatment wi …
Melanoma was prevented by inhibitors of mTorc1 (rapamycin) or MEK1/2 (PD325901) but, upon cessation of drug administration, mice deve …
Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma.
Cancer Cell. 2002 Apr;1(3):279-88. doi: 10.1016/s1535-6108(02)00045-4.
Cancer Cell. 2002.
PMID: 12086864
Free article.
Gene expression profiling identified human melanoma cells demonstrating increased cell motility and invasiveness. The gene WNT5A best determined in vitro invasive behavior. ...There was, however, a dramatic increase in activated PKC. In d …
Gene expression profiling identified human melanoma cells demonstrating increased cell motility and invasiveness …
Pleural Melanoma Metastasis.
Ann Thorac Surg. 2021 Aug;112(2):e103-e105. doi: 10.1016/j.athoracsur.2020.09.088. Epub 2021 Jan 7.
Ann Thorac Surg. 2021.
PMID: 33421399
Melanomas represent 3% of all skin cancers but 65% of skin cancer deaths. Metastatic melanoma constitutes about 5% of all secondary malignancies of the lung, yet only 2% of patients with thoracic metastases have pleural effusions. ...Biopsies confirmed …
Melanomas represent 3% of all skin cancers but 65% of skin cancer deaths. Metastatic melanoma constitutes about 5% of a …
Uveal tumour resection.
Br J Ophthalmol. 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213.
Br J Ophthalmol. 2001.
PMID: 11567967
Free PMC article.
Eight patients developed metastases; all metastatic events developed in patients with tumours that involved the choroid, and seven of eight were mixed cell melanomas. CONCLUSIONS: 76% of eyes were retained and 53% of these had a final visual acuity of > or …
Eight patients developed metastases; all metastatic events developed in patients with tumours that involved the choroid, and seven of …
Radiation Therapy for Metastatic Melanoma.
Dermatol Clin. 2025 Jul;43(3):495-501. doi: 10.1016/j.det.2025.03.013. Epub 2025 May 14.
Dermatol Clin. 2025.
PMID: 40581429
Review.
Metastatic melanoma is an aggressive and treatment-resistant skin cancer with a low 5-year survival rate of 27%. Historically considered radioresistant, melanoma's response to radiation therapy (RT) has evolved, especially when integrated with systemic …
Metastatic melanoma is an aggressive and treatment-resistant skin cancer with a low 5-year survival rate of 27%. Historically …
Melanoma of the small intestine.
Lancet Oncol. 2009 May;10(5):516-21. doi: 10.1016/S1470-2045(09)70036-1.
Lancet Oncol. 2009.
PMID: 19410196
Review.
Primary intestinal melanoma is extremely rare, whereas metastatic melanoma of the small bowel is common because of the tendency for cutaneous melanoma to metastasise to the gastrointestinal tract. Because distinguishing between primary and metastati …
Primary intestinal melanoma is extremely rare, whereas metastatic melanoma of the small bowel is common because of the …
Eye-wall resection.
Trans Am Ophthalmol Soc. 2000;98:153-9; discussion 159-61.
Trans Am Ophthalmol Soc. 2000.
PMID: 11190019
Free PMC article.
Metastases developed in 8 patients; all metastatic events developed in patients with tumors that involved the choroid, and 7 of 8 were mixed cell melanomas. CONCLUSIONS: Seventy percent of eyes were retained, and 56% of these had a final visual acuity of 20/4 …
Metastases developed in 8 patients; all metastatic events developed in patients with tumors that involved the choroid, and 7 of 8 wer …
Metastatic disease from uveal melanoma: treatment options and future prospects.
Br J Ophthalmol. 2017 Jan;101(1):38-44. doi: 10.1136/bjophthalmol-2016-309034. Epub 2016 Aug 29.
Br J Ophthalmol. 2017.
PMID: 27574175
Free PMC article.
Review.
Uveal melanoma represents 85% of all ocular melanomas and up to 50% of patients develop metastatic disease. ...This review explores the biology of uveal melanoma and how this relates to ongoing trials of targeted therapies in the metastatic dis …
Uveal melanoma represents 85% of all ocular melanomas and up to 50% of patients develop metastatic disease. ...This re …
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