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Therapeutic strategies for Alzheimer's disease.
Wolfe MS. Wolfe MS. Nat Rev Drug Discov. 2002 Nov;1(11):859-66. doi: 10.1038/nrd938. Nat Rev Drug Discov. 2002. PMID: 12415246 Review.
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ. Wolfe MS, et al. Biochemistry. 1999 Apr 13;38(15):4720-7. doi: 10.1021/bi982562p. Biochemistry. 1999. PMID: 10200159
We recently described a difluoro ketone peptidomimetic (1) that blocks Abeta production at the gamma-secretase level [Wolfe, M. ...
We recently described a difluoro ketone peptidomimetic (1) that blocks Abeta production at the gamma-secretase level [Wolfe, M. ...
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. De Strooper B, et al. Nature. 1999 Apr 8;398(6727):518-22. doi: 10.1038/19083. Nature. 1999. PMID: 10206645
In search of gamma-secretase: presenilin at the cutting edge.
Selkoe DJ, Wolfe MS. Selkoe DJ, et al. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5690-2. doi: 10.1073/pnas.97.11.5690. Proc Natl Acad Sci U S A. 2000. PMID: 10823929 Free PMC article. No abstract available.
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Esler WP, et al. Nat Cell Biol. 2000 Jul;2(7):428-34. doi: 10.1038/35017062. Nat Cell Biol. 2000. PMID: 10878808
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Xia W, et al. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9299-304. doi: 10.1073/pnas.97.16.9299. Proc Natl Acad Sci U S A. 2000. PMID: 10922078 Free PMC article.
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