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Page 1
Microgravity and bone cell mechanosensitivity.
Burger EH, Klein-Nulend J. Burger EH, et al. Bone. 1998 May;22(5 Suppl):127S-130S. doi: 10.1016/s8756-3282(98)00010-6. Bone. 1998. PMID: 9600768 Review.
Bone cells, in particular osteocytes, are extremely sensitive to mechanical stress, a quality that is probably linked to the process of mechanical adaptation (Wolff's law). ...Disruption of the actin-cytoskeleton abolishes the response to stress, sugge …
Bone cells, in particular osteocytes, are extremely sensitive to mechanical stress, a quality that is probably linked to the process …
Mechanisms of bone response to injury.
Dittmer KE, Firth EC. Dittmer KE, et al. J Vet Diagn Invest. 2017 Jul;29(4):385-395. doi: 10.1177/1040638716679861. Epub 2017 Jan 6. J Vet Diagn Invest. 2017. PMID: 28061633
Bone, despite its relatively inert appearance, is a tissue that is capable of adapting to its environment. Wolff's law, first described in the 19th century, describes the ability of bone to change structure depending on the mechanical forces applied to it. .. …
Bone, despite its relatively inert appearance, is a tissue that is capable of adapting to its environment. Wolff's law, …
Three-dimensional trabecular alignment model.
Bono ES, Smolinski P, Casagranda A, Xu J. Bono ES, et al. Comput Methods Biomech Biomed Engin. 2003 Apr;6(2):125-31. doi: 10.1080/1025584031000091687. Comput Methods Biomech Biomed Engin. 2003. PMID: 12745426
Trabecular alignment theory has been used to quantify Wolff's Law of bone remodeling. A three-dimensional finite element scheme was developed to analyze the bone remodeling phenomenon. ...
Trabecular alignment theory has been used to quantify Wolff's Law of bone remodeling. A three-dimensional finite elemen …
Investigation of the regulation of bone mass by mechanical loading: from quantitative cytochemistry to gene array.
Skerry TM, Suva LJ. Skerry TM, et al. Cell Biochem Funct. 2003 Sep;21(3):223-9. doi: 10.1002/cbf.1077. Cell Biochem Funct. 2003. PMID: 12910474 Review.
This was the first demonstration of an ability of osteocytes to respond to an external mechanical event and in effect provided a mechanistic link for the fundamental principle of what is known as Wolff's law of bone remodelling. ...During such studies, …
This was the first demonstration of an ability of osteocytes to respond to an external mechanical event and in effect provided a mech …
Boning up on Wolff's Law: mechanical regulation of the cells that make and maintain bone.
Chen JH, Liu C, You L, Simmons CA. Chen JH, et al. J Biomech. 2010 Jan 5;43(1):108-18. doi: 10.1016/j.jbiomech.2009.09.016. Epub 2009 Oct 8. J Biomech. 2010. PMID: 19818443 Review.
Bone tissue forms and is remodeled in response to the mechanical forces that it experiences, a phenomenon described by Wolff's Law. Mechanically induced formation and adaptation of bone tissue is mediated by bone cells that sense and respond to local mechanic …
Bone tissue forms and is remodeled in response to the mechanical forces that it experiences, a phenomenon described by Wolff's …
Experimental studies of bone mechanoadaptation: bridging in vitro and in vivo studies with multiscale systems.
Brown GN, Sattler RL, Guo XE. Brown GN, et al. Interface Focus. 2016 Feb 6;6(1):20150071. doi: 10.1098/rsfs.2015.0071. Interface Focus. 2016. PMID: 26855756 Free PMC article.
Despite advancements in technology and science over the last century, the mechanisms underlying Wolff's law-bone structure adaptation in response to physical stimuli-remain poorly understood, limiting the ability to effectively treat and prevent skeletal dise …
Despite advancements in technology and science over the last century, the mechanisms underlying Wolff's law-bone struct …