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Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA.
Wolff B, Sanglier JJ, Wang Y. Wolff B, et al. Chem Biol. 1997 Feb;4(2):139-47. doi: 10.1016/s1074-5521(97)90257-x. Chem Biol. 1997. PMID: 9190288
Rev-dependent export of mRNA into the cytoplasm is also blocked by leptomycin B, which inhibits Rev-dependent, but not Rev-independent gene expression in a short-term transfection assay. In primary human monocytes, leptomycin B suppresses HIV-1 replication. CONCLUSI …
Rev-dependent export of mRNA into the cytoplasm is also blocked by leptomycin B, which inhibits Rev-dependent, but not Rev-independen …
6-(2-adamantan-2-ylidene-hydroxybenzoxazole)-O-sulfamate: a potent non-steroidal irreversible inhibitor of human steroid sulfatase.
Schreiner EP, Wolff B, Winiski AP, Billich A. Schreiner EP, et al. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4313-6. doi: 10.1016/j.bmcl.2003.09.050. Bioorg Med Chem Lett. 2003. PMID: 14643316
Highly straightforward, condensation of 2-methyl-6-hydroxybenzoxazole with 2-adamantanone, subsequent elimination of water and sulfamoylation provide the title compound in 45% overall yield from the inexpensive 2,4-dihydroxyacetophenone. 1 was found to be a potent irreversible in …
Highly straightforward, condensation of 2-methyl-6-hydroxybenzoxazole with 2-adamantanone, subsequent elimination of water and sulfamoylatio …
Some aspects of IL-8 pathophysiology. III: Chemokine interaction with endothelial cells.
Rot A, Hub E, Middleton J, Pons F, Rabeck C, Thierer K, Wintle J, Wolff B, Zsak M, Dukor P. Rot A, et al. J Leukoc Biol. 1996 Jan;59(1):39-44. doi: 10.1002/jlb.59.1.39. J Leukoc Biol. 1996. PMID: 8558065 Review.
Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.
Ruhl M, Himmelspach M, Bahr GM, Hammerschmid F, Jaksche H, Wolff B, Aschauer H, Farrington GK, Probst H, Bevec D, et al. Ruhl M, et al. J Cell Biol. 1993 Dec;123(6 Pt 1):1309-20. doi: 10.1083/jcb.123.6.1309. J Cell Biol. 1993. PMID: 8253832 Free PMC article.
Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication.
Steinkasserer A, Harrison R, Billich A, Hammerschmid F, Werner G, Wolff B, Peichl P, Palfi G, Schnitzel W, Mlynar E, et al. Steinkasserer A, et al. J Virol. 1995 Feb;69(2):814-24. doi: 10.1128/JVI.69.2.814-824.1995. J Virol. 1995. PMID: 7815548 Free PMC article.
Microbial conversion products of leptomycin B.
Kuhnt M, Bitsch F, Ponelle M, Sanglier JJ, Wang Y, Wolff B. Kuhnt M, et al. Appl Environ Microbiol. 1998 Feb;64(2):714-20. doi: 10.1128/AEM.64.2.714-720.1998. Appl Environ Microbiol. 1998. PMID: 9464413 Free PMC article.
Leptomycin B (LMB), a secondary metabolite produced by Streptomyces sp. strain ATS 1287, with known antifungal and antitumor effects, inhibits the nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 regulatory protein Rev and exhibits significant an …
Leptomycin B (LMB), a secondary metabolite produced by Streptomyces sp. strain ATS 1287, with known antifungal and antitumor effects, …
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1.
Kudo N, Wolff B, Sekimoto T, Schreiner EP, Yoneda Y, Yanagida M, Horinouchi S, Yoshida M. Kudo N, et al. Exp Cell Res. 1998 Aug 1;242(2):540-7. doi: 10.1006/excr.1998.4136. Exp Cell Res. 1998. PMID: 9683540
Leptomycin B (LMB) is a Streptomyces metabolite that inhibits nuclear export of the human immunodeficiency virus type 1 regulatory protein Rev at low nanomolar concentrations. ...
Leptomycin B (LMB) is a Streptomyces metabolite that inhibits nuclear export of the human immunodeficiency virus type 1 regulatory pr …
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