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Adipose-derived circulating miRNAs regulate gene expression in other tissues.
Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR. Thomou T, et al. Among authors: wolfrum c. Nature. 2017 Feb 23;542(7642):450-455. doi: 10.1038/nature21365. Epub 2017 Feb 15. Nature. 2017. PMID: 28199304 Free PMC article.
An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice.
Rohm M, Schäfer M, Laurent V, Üstünel BE, Niopek K, Algire C, Hautzinger O, Sijmonsma TP, Zota A, Medrikova D, Pellegata NS, Ryden M, Kulyte A, Dahlman I, Arner P, Petrovic N, Cannon B, Amri EZ, Kemp BE, Steinberg GR, Janovska P, Kopecky J, Wolfrum C, Blüher M, Berriel Diaz M, Herzig S. Rohm M, et al. Among authors: wolfrum c. Nat Med. 2016 Oct;22(10):1120-1130. doi: 10.1038/nm.4171. Epub 2016 Aug 29. Nat Med. 2016. PMID: 27571348
Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.
Sun W, Dong H, Becker AS, Dapito DH, Modica S, Grandl G, Opitz L, Efthymiou V, Straub LG, Sarker G, Balaz M, Balazova L, Perdikari A, Kiehlmann E, Bacanovic S, Zellweger C, Peleg-Raibstein D, Pelczar P, Reik W, Burger IA, von Meyenn F, Wolfrum C. Sun W, et al. Among authors: wolfrum c. Nat Med. 2018 Sep;24(9):1372-1383. doi: 10.1038/s41591-018-0102-y. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988127
ASK1 inhibits browning of white adipose tissue in obesity.
Lucchini FC, Wueest S, Challa TD, Item F, Modica S, Borsigova M, Haim Y, Wolfrum C, Rudich A, Konrad D. Lucchini FC, et al. Among authors: wolfrum c. Nat Commun. 2020 Apr 2;11(1):1642. doi: 10.1038/s41467-020-15483-7. Nat Commun. 2020. PMID: 32242025 Free PMC article.
Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice.
de Jong JMA, Sun W, Pires ND, Frontini A, Balaz M, Jespersen NZ, Feizi A, Petrovic K, Fischer AW, Bokhari MH, Niemi T, Nuutila P, Cinti S, Nielsen S, Scheele C, Virtanen K, Cannon B, Nedergaard J, Wolfrum C, Petrovic N. de Jong JMA, et al. Among authors: wolfrum c. Nat Metab. 2019 Aug;1(8):830-843. doi: 10.1038/s42255-019-0101-4. Epub 2019 Aug 19. Nat Metab. 2019. PMID: 32694768
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis.
Sun W, Dong H, Balaz M, Slyper M, Drokhlyansky E, Colleluori G, Giordano A, Kovanicova Z, Stefanicka P, Balazova L, Ding L, Husted AS, Rudofsky G, Ukropec J, Cinti S, Schwartz TW, Regev A, Wolfrum C. Sun W, et al. Among authors: wolfrum c. Nature. 2020 Nov;587(7832):98-102. doi: 10.1038/s41586-020-2856-x. Epub 2020 Oct 28. Nature. 2020. PMID: 33116305
203 results