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1,290 results
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The role of ATM in response to metformin treatment and activation of AMPK.
Woods A, Leiper JM, Carling D. Woods A, et al. Nat Genet. 2012 Mar 28;44(4):360-1. doi: 10.1038/ng.2235. Nat Genet. 2012. PMID: 22456733 No abstract available.
Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495.
Spengler K, Zibrova D, Woods A, Langendorf CG, Scott JW, Carling D, Heller R. Spengler K, et al. Among authors: woods a. Biochem J. 2020 Sep 18;477(17):3453-3469. doi: 10.1042/BCJ20200555. Biochem J. 2020. PMID: 32869834
AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B.
Johanns M, Lai YC, Hsu MF, Jacobs R, Vertommen D, Van Sande J, Dumont JE, Woods A, Carling D, Hue L, Viollet B, Foretz M, Rider MH. Johanns M, et al. Among authors: woods a. Nat Commun. 2016 Mar 8;7:10856. doi: 10.1038/ncomms10856. Nat Commun. 2016. PMID: 26952277 Free PMC article.
Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.
Siggs OM, Stockenhuber A, Deobagkar-Lele M, Bull KR, Crockford TL, Kingston BL, Crawford G, Anzilotti C, Steeples V, Ghaffari S, Czibik G, Bellahcene M, Watkins H, Ashrafian H, Davies B, Woods A, Carling D, Yavari A, Beutler B, Cornall RJ. Siggs OM, et al. Among authors: woods a. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3706-15. doi: 10.1073/pnas.1607592113. Epub 2016 Jun 14. Proc Natl Acad Sci U S A. 2016. PMID: 27303042 Free PMC article.
Mammalian γ2 AMPK regulates intrinsic heart rate.
Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H. Yavari A, et al. Among authors: woods a. Nat Commun. 2017 Nov 2;8(1):1258. doi: 10.1038/s41467-017-01342-5. Nat Commun. 2017. PMID: 29097735 Free PMC article.
AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue.
Pollard AE, Martins L, Muckett PJ, Khadayate S, Bornot A, Clausen M, Admyre T, Bjursell M, Fiadeiro R, Wilson L, Whilding C, Kotiadis VN, Duchen MR, Sutton D, Penfold L, Sardini A, Bohlooly-Y M, Smith DM, Read JA, Snowden MA, Woods A, Carling D. Pollard AE, et al. Among authors: woods a. Nat Metab. 2019 Mar;1(3):340-349. doi: 10.1038/s42255-019-0036-9. Epub 2019 Feb 25. Nat Metab. 2019. PMID: 30887000 Free PMC article. No abstract available.
Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis.
Woods A, Vertommen D, Neumann D, Turk R, Bayliss J, Schlattner U, Wallimann T, Carling D, Rider MH. Woods A, et al. J Biol Chem. 2003 Aug 1;278(31):28434-42. doi: 10.1074/jbc.M303946200. Epub 2003 May 21. J Biol Chem. 2003. PMID: 12764152
LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice.
Woods A, Heslegrave AJ, Muckett PJ, Levene AP, Clements M, Mobberley M, Ryder TA, Abu-Hayyeh S, Williamson C, Goldin RD, Ashworth A, Withers DJ, Carling D. Woods A, et al. Biochem J. 2011 Feb 15;434(1):49-60. doi: 10.1042/BJ20101721. Biochem J. 2011. PMID: 21118154 Free PMC article.
Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1.
Gaude H, Aznar N, Delay A, Bres A, Buchet-Poyau K, Caillat C, Vigouroux A, Rogon C, Woods A, Vanacker JM, Höhfeld J, Perret C, Meyer P, Billaud M, Forcet C. Gaude H, et al. Among authors: woods a. Oncogene. 2012 Mar 22;31(12):1582-91. doi: 10.1038/onc.2011.342. Epub 2011 Aug 22. Oncogene. 2012. PMID: 21860411
CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis.
Penfold L, Woods A, Muckett P, Nikitin AY, Kent TR, Zhang S, Graham R, Pollard A, Carling D. Penfold L, et al. Among authors: woods a. Cancer Res. 2018 Dec 15;78(24):6747-6761. doi: 10.1158/0008-5472.CAN-18-0585. Epub 2018 Sep 21. Cancer Res. 2018. PMID: 30242113 Free PMC article.
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