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Three-dimensional in vitro models answer the right questions in ADPKD cystogenesis.
Dixon EE, Woodward OM. Dixon EE, et al. Among authors: woodward om. Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F332-F335. doi: 10.1152/ajprenal.00126.2018. Epub 2018 Apr 25. Am J Physiol Renal Physiol. 2018. PMID: 29693448 Free PMC article. Review.
Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease.
Li Y, Santoso NG, Yu S, Woodward OM, Qian F, Guggino WB. Li Y, et al. Among authors: woodward om. J Biol Chem. 2009 Dec 25;284(52):36431-41. doi: 10.1074/jbc.M109.068916. Epub 2009 Oct 23. J Biol Chem. 2009. PMID: 19854836 Free PMC article.
Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.
Woodward OM, Li Y, Yu S, Greenwell P, Wodarczyk C, Boletta A, Guggino WB, Qian F. Woodward OM, et al. PLoS One. 2010 Aug 23;5(8):e12305. doi: 10.1371/journal.pone.0012305. PLoS One. 2010. PMID: 20808796 Free PMC article.
ABCG2: the molecular mechanisms of urate secretion and gout.
Woodward OM. Woodward OM. Am J Physiol Renal Physiol. 2015 Sep 15;309(6):F485-8. doi: 10.1152/ajprenal.00242.2015. Epub 2015 Jul 1. Am J Physiol Renal Physiol. 2015. PMID: 26136557 Free PMC article. Review.
Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels.
Tin A, Li Y, Brody JA, Nutile T, Chu AY, Huffman JE, Yang Q, Chen MH, Robinson-Cohen C, Macé A, Liu J, Demirkan A, Sorice R, Sedaghat S, Swen M, Yu B, Ghasemi S, Teumer A, Vollenweider P, Ciullo M, Li M, Uitterlinden AG, Kraaij R, Amin N, van Rooij J, Kutalik Z, Dehghan A, McKnight B, van Duijn CM, Morrison A, Psaty BM, Boerwinkle E, Fox CS, Woodward OM, Köttgen A. Tin A, et al. Among authors: woodward om. Nat Commun. 2018 Oct 12;9(1):4228. doi: 10.1038/s41467-018-06620-4. Nat Commun. 2018. PMID: 30315176 Free PMC article.
The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion.
Hoque KM, Dixon EE, Lewis RM, Allan J, Gamble GD, Phipps-Green AJ, Halperin Kuhns VL, Horne AM, Stamp LK, Merriman TR, Dalbeth N, Woodward OM. Hoque KM, et al. Among authors: woodward om. Nat Commun. 2020 Jun 2;11(1):2767. doi: 10.1038/s41467-020-16525-w. Nat Commun. 2020. PMID: 32488095 Free PMC article.
GDNF drives rapid tubule morphogenesis in a novel 3D in vitro model for ADPKD.
Dixon EE, Maxim DS, Halperin Kuhns VL, Lane-Harris AC, Outeda P, Ewald AJ, Watnick TJ, Welling PA, Woodward OM. Dixon EE, et al. Among authors: woodward om. J Cell Sci. 2020 Jul 16;133(14):jcs249557. doi: 10.1242/jcs.249557. J Cell Sci. 2020. PMID: 32513820 Free PMC article.
Transcomplementation by a truncation mutant of cystic fibrosis transmembrane conductance regulator (CFTR) enhances ΔF508 processing through a biomolecular interaction.
Cebotaru L, Woodward O, Cebotaru V, Guggino WB. Cebotaru L, et al. J Biol Chem. 2013 Apr 12;288(15):10505-12. doi: 10.1074/jbc.M112.420489. Epub 2013 Mar 5. J Biol Chem. 2013. PMID: 23463513 Free PMC article.
Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.
Woodward OM, Köttgen A, Coresh J, Boerwinkle E, Guggino WB, Köttgen M. Woodward OM, et al. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10338-42. doi: 10.1073/pnas.0901249106. Epub 2009 Jun 8. Proc Natl Acad Sci U S A. 2009. PMID: 19506252 Free PMC article.
Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons.
Kim SH, Lee Y, Akitake B, Woodward OM, Guggino WB, Montell C. Kim SH, et al. Among authors: woodward om. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8440-5. doi: 10.1073/pnas.1001425107. Epub 2010 Apr 19. Proc Natl Acad Sci U S A. 2010. PMID: 20404155 Free PMC article.
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