Workman P - Search Results

1

Nitroimidazole bioreductive metabolism. Quantitation and characterisation of mouse tissue benznidazole nitroreductases in vivo and in vitro.

Walton MI, Workman P. Walton MI, et al. Among authors: workman p. Biochem Pharmacol. 1987 Mar 15;36(6):887-96. doi: 10.1016/0006-2952(87)90181-x. Biochem Pharmacol. 1987. PMID: 3105539

2

Enzyme activated anti-tumor agents--IV. Comparative kinetics of N,N-p-di-2-chloroethylaminophenyl phosphate hydrolysis catalysed by phosphatases of normal and neoplastic tissues.

Workman P, Double JA. Workman P, et al. Biochem Pharmacol. 1978 Jan 15;27(2):199-202. doi: 10.1016/0006-2952(78)90301-5. Biochem Pharmacol. 1978. PMID: 623675 No abstract available.

3

The enzymology of doxorubicin quinone reduction in tumour tissue.

Cummings J, Allan L, Willmott N, Riley R, Workman P, Smyth JF. Cummings J, et al. Among authors: workman p. Biochem Pharmacol. 1992 Dec 1;44(11):2175-83. doi: 10.1016/0006-2952(92)90344-i. Biochem Pharmacol. 1992. PMID: 1472082

4

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.

Walton MI, Wolf CR, Workman P. Walton MI, et al. Among authors: workman p. Biochem Pharmacol. 1992 Jul 22;44(2):251-9. doi: 10.1016/0006-2952(92)90007-6. Biochem Pharmacol. 1992. PMID: 1642640

5

Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells.

Riley RJ, Workman P. Riley RJ, et al. Among authors: workman p. Biochem Pharmacol. 1992 Jan 22;43(2):167-74. doi: 10.1016/0006-2952(92)90274-m. Biochem Pharmacol. 1992. PMID: 1739405

6

Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin alpha-(1-aziridinomethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069).

Binger M, Workman P. Binger M, et al. Among authors: workman p. Cancer Chemother Pharmacol. 1991;29(1):37-47. doi: 10.1007/BF00686334. Cancer Chemother Pharmacol. 1991. PMID: 1742848

7

Doxorubicin-3'-NH-oestrone-17-oxime-ethyl-carbonyl, a doxorubicin-oestrone conjugate that does not redox cycle in rat liver microsomes.

Hartman NG, Patterson LH, Workman P, Suarato A, Angelucci F. Hartman NG, et al. Among authors: workman p. Biochem Pharmacol. 1990 Sep 1;40(5):1164-7. doi: 10.1016/0006-2952(90)90511-i. Biochem Pharmacol. 1990. PMID: 2167681

8

Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.

Walton MI, Workman P. Walton MI, et al. Among authors: workman p. Biochem Pharmacol. 1990 Jun 1;39(11):1735-42. doi: 10.1016/0006-2952(90)90119-6. Biochem Pharmacol. 1990. PMID: 2344370

9

Improved cellular accumulation is characteristic of anthracyclines which retain high activity in multidrug resistant cell lines, alone or in combination with verapamil or cyclosporin A.

Coley HM, Twentyman PR, Workman P. Coley HM, et al. Among authors: workman p. Biochem Pharmacol. 1989 Dec 15;38(24):4467-75. doi: 10.1016/0006-2952(89)90658-8. Biochem Pharmacol. 1989. PMID: 2604747

10

Stimulation by localized tumor hyperthermia of reductive bioactivation of 2-nitroimidazole benznidazole in mice.

Walton MI, Bleehen NM, Workman P. Walton MI, et al. Among authors: workman p. Cancer Res. 1989 May 1;49(9):2351-5. Cancer Res. 1989. PMID: 2706623

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