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Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.
Wormhoudt LW, Commandeur JN, Vermeulen NP. Wormhoudt LW, et al. Crit Rev Toxicol. 1999 Jan;29(1):59-124. doi: 10.1080/10408449991349186. Crit Rev Toxicol. 1999. PMID: 10066160 Review.
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP. Wormhoudt LW, et al. Drug Metab Dispos. 1997 Apr;25(4):508-15. Drug Metab Dispos. 1997. PMID: 9107551
Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes.
Wormhoudt LW, Ploemen JH, de Waziers I, Commandeur JN, Beaune PH, van Bladeren PJ, Vermeulen NP. Wormhoudt LW, et al. Chem Biol Interact. 1996 Sep 6;101(3):175-92. doi: 10.1016/0009-2797(96)03723-4. Chem Biol Interact. 1996. PMID: 8870687
Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions.
Brakenhoff JP, Commandeur JN, Wormhoudt LW, Groot EJ, Vermeulen NP. Brakenhoff JP, et al. Among authors: wormhoudt lw. Carcinogenesis. 1996 Apr;17(4):715-24. doi: 10.1093/carcin/17.4.715. Carcinogenesis. 1996. PMID: 8625482
Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats.
Wormhoudt LW, Ploemen JH, Commandeur JN, van Ommen B, van Bladeren P, Vermeulen NP. Wormhoudt LW, et al. Chem Biol Interact. 1996 Jan 5;99(1-3):41-53. doi: 10.1016/0009-2797(95)03659-8. Chem Biol Interact. 1996. PMID: 8620578
Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it.
Vermeulen NP, Commandeur JN, Groot EJ, Wormhoudt LW, Ramnatshing S, Li QJ, Brakenhoff JP. Vermeulen NP, et al. Among authors: wormhoudt lw. Chem Biol Interact. 1998 Apr 3;110(3):139-58. doi: 10.1016/s0009-2797(98)00004-0. Chem Biol Interact. 1998. PMID: 9609383
A physiologically-based pharmacokinetic(PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism.
Hissink AM, Wormhoudt LW, Sherratt PJ, Hayes JD, Commandeur JN, Vermeulen NP, van Bladeren PJ. Hissink AM, et al. Among authors: wormhoudt lw. Food Chem Toxicol. 2000 Aug;38(8):707-16. doi: 10.1016/s0278-6915(00)00059-4. Food Chem Toxicol. 2000. PMID: 10908818
The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: the case of ethylene dibromide.
Ploemen JP, Wormhoudt LW, Haenen GR, Oudshoorn MJ, Commandeur JN, Vermeulen NP, de Waziers I, Beaune PH, Watabe T, van Bladeren PJ. Ploemen JP, et al. Among authors: wormhoudt lw. Toxicol Appl Pharmacol. 1997 Mar;143(1):56-69. doi: 10.1006/taap.1996.8004. Toxicol Appl Pharmacol. 1997. PMID: 9073592
In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate.
Ploemen JP, van Iersel ML, Wormhoudt LW, Commandeur JN, Vermeulen NP, van Bladeren PJ. Ploemen JP, et al. Among authors: wormhoudt lw. Biochem Pharmacol. 1996 Jul 26;52(2):197-204. doi: 10.1016/0006-2952(96)00142-6. Biochem Pharmacol. 1996. PMID: 8694843
Disposition of 1,2-[14C]Dibromoethane in male Wistar rats.
Wormhoudt LW, Hissink AM, Commandeur JN, van Bladeren PJ, Vermeulen NP. Wormhoudt LW, et al. Drug Metab Dispos. 1998 May;26(5):437-47. Drug Metab Dispos. 1998. PMID: 9571225
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