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Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems.
Arbing MA, Handelman SK, Kuzin AP, Verdon G, Wang C, Su M, Rothenbacher FP, Abashidze M, Liu M, Hurley JM, Xiao R, Acton T, Inouye M, Montelione GT, Woychik NA, Hunt JF. Arbing MA, et al. Among authors: woychik na. Structure. 2010 Aug 11;18(8):996-1010. doi: 10.1016/j.str.2010.04.018. Structure. 2010. PMID: 20696400 Free PMC article.
Doc toxin is a kinase that inactivates elongation factor Tu.
Cruz JW, Rothenbacher FP, Maehigashi T, Lane WS, Dunham CM, Woychik NA. Cruz JW, et al. Among authors: woychik na. J Biol Chem. 2014 Mar 14;289(11):7788-98. doi: 10.1074/jbc.M113.544429. Epub 2014 Jan 21. J Biol Chem. 2014. PMID: 24448800 Free PMC article.
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