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GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.
Wieser R, Wrana JL, Massagué J. Wieser R, et al. Among authors: wrana jl. EMBO J. 1995 May 15;14(10):2199-208. EMBO J. 1995. PMID: 7774578 Free PMC article.
Extracellular matrix-induced transforming growth factor-beta receptor signaling dynamics.
Garamszegi N, Garamszegi SP, Samavarchi-Tehrani P, Walford E, Schneiderbauer MM, Wrana JL, Scully SP. Garamszegi N, et al. Among authors: wrana jl. Oncogene. 2010 Apr 22;29(16):2368-80. doi: 10.1038/onc.2009.514. Epub 2010 Jan 25. Oncogene. 2010. PMID: 20101206
Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.
Sirard C, Kim S, Mirtsos C, Tadich P, Hoodless PA, Itié A, Maxson R, Wrana JL, Mak TW. Sirard C, et al. Among authors: wrana jl. J Biol Chem. 2000 Jan 21;275(3):2063-70. doi: 10.1074/jbc.275.3.2063. J Biol Chem. 2000. PMID: 10636910
The TGF-beta family and its composite receptors.
Massagué J, Attisano L, Wrana JL. Massagué J, et al. Among authors: wrana jl. Trends Cell Biol. 1994 May;4(5):172-8. doi: 10.1016/0962-8924(94)90202-x. Trends Cell Biol. 1994. PMID: 14731645
TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.
Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL. Bonni S, et al. Among authors: wrana jl. Nat Cell Biol. 2001 Jun;3(6):587-95. doi: 10.1038/35078562. Nat Cell Biol. 2001. PMID: 11389444
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.
Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL. Kavsak P, et al. Among authors: wrana jl. Mol Cell. 2000 Dec;6(6):1365-75. doi: 10.1016/s1097-2765(00)00134-9. Mol Cell. 2000. PMID: 11163210
Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily.
Barbara NP, Wrana JL, Letarte M. Barbara NP, et al. Among authors: wrana jl. J Biol Chem. 1999 Jan 8;274(2):584-94. doi: 10.1074/jbc.274.2.584. J Biol Chem. 1999. PMID: 9872992
Activation of signalling by the activin receptor complex.
Attisano L, Wrana JL, Montalvo E, Massagué J. Attisano L, et al. Among authors: wrana jl. Mol Cell Biol. 1996 Mar;16(3):1066-73. doi: 10.1128/mcb.16.3.1066. Mol Cell Biol. 1996. PMID: 8622651 Free PMC article.
Betaglycan presents ligand to the TGF beta signaling receptor.
López-Casillas F, Wrana JL, Massagué J. López-Casillas F, et al. Among authors: wrana jl. Cell. 1993 Jul 2;73(7):1435-44. doi: 10.1016/0092-8674(93)90368-z. Cell. 1993. PMID: 8391934
Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region.
Wieser R, Attisano L, Wrana JL, Massagué J. Wieser R, et al. Among authors: wrana jl. Mol Cell Biol. 1993 Dec;13(12):7239-47. doi: 10.1128/mcb.13.12.7239. Mol Cell Biol. 1993. PMID: 8246946 Free PMC article.
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