Wright GE - Search Results

1

In vitro antimicrobial activities of novel anilinouracils which selectively inhibit DNA polymerase III of gram-positive bacteria.

Daly JS, Giehl TJ, Brown NC, Zhi C, Wright GE, Ellison RT 3rd. Daly JS, et al. Among authors: wright ge. Antimicrob Agents Chemother. 2000 Aug;44(8):2217-21. doi: 10.1128/AAC.44.8.2217-2221.2000. Antimicrob Agents Chemother. 2000. PMID: 10898708 Free PMC article.

2

Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and Gram-positive bacterial growth.

Zhi C, Long ZY, Gambino J, Xu WC, Brown NC, Barnes M, Butler M, LaMarr W, Wright GE. Zhi C, et al. Among authors: wright ge. J Med Chem. 2003 Jun 19;46(13):2731-9. doi: 10.1021/jm020591z. J Med Chem. 2003. PMID: 12801236

3

Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound.

Butler MM, Lamarr WA, Foster KA, Barnes MH, Skow DJ, Lyden PT, Kustigian LM, Zhi C, Brown NC, Wright GE, Bowlin TL. Butler MM, et al. Among authors: wright ge. Antimicrob Agents Chemother. 2007 Jan;51(1):119-27. doi: 10.1128/AAC.01311-05. Epub 2006 Oct 30. Antimicrob Agents Chemother. 2007. PMID: 17074800 Free PMC article.

4

6-Anilinouracil-based inhibitors of Bacillus subtilis DNA polymerase III: antipolymerase and antimicrobial structure-activity relationships based on substitution at uracil N3.

Tarantino PM Jr, Zhi C, Gambino JJ, Wright GE, Brown NC. Tarantino PM Jr, et al. Among authors: wright ge. J Med Chem. 1999 Jun 3;42(11):2035-40. doi: 10.1021/jm980693i. J Med Chem. 1999. PMID: 10354411

5

Inhibitors of DNA polymerase III as novel antimicrobial agents against gram-positive eubacteria.

Tarantino PM Jr, Zhi C, Wright GE, Brown NC. Tarantino PM Jr, et al. Among authors: wright ge. Antimicrob Agents Chemother. 1999 Aug;43(8):1982-7. doi: 10.1128/AAC.43.8.1982. Antimicrob Agents Chemother. 1999. PMID: 10428923 Free PMC article.

6

Active site directed inhibitors of replication-specific bacterial DNA polymerases.

Wright GE, Brown NC, Xu WC, Long ZY, Zhi C, Gambino JJ, Barnes MH, Butler MM. Wright GE, et al. Bioorg Med Chem Lett. 2005 Feb 1;15(3):729-32. doi: 10.1016/j.bmcl.2004.11.016. Bioorg Med Chem Lett. 2005. PMID: 15664846

7

Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils.

Zhi C, Long ZY, Manikowski A, Brown NC, Tarantino PM Jr, Holm K, Dix EJ, Wright GE, Foster KA, Butler MM, LaMarr WA, Skow DJ, Motorina I, Lamothe S, Storer R. Zhi C, et al. Among authors: wright ge. J Med Chem. 2005 Nov 3;48(22):7063-74. doi: 10.1021/jm050517r. J Med Chem. 2005. PMID: 16250666

8

Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors.

Zhi C, Long ZY, Manikowski A, Comstock J, Xu WC, Brown NC, Tarantino PM Jr, Holm KA, Dix EJ, Wright GE, Barnes MH, Butler MM, Foster KA, LaMarr WA, Bachand B, Bethell R, Cadilhac C, Charron S, Lamothe S, Motorina I, Storer R. Zhi C, et al. Among authors: wright ge. J Med Chem. 2006 Feb 23;49(4):1455-65. doi: 10.1021/jm0510023. J Med Chem. 2006. PMID: 16480282 Free PMC article.

9

7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity.

Xu WC, Wright GE, Brown NC, Long ZY, Zhi CX, Dvoskin S, Gambino JJ, Barnes MH, Butler MM. Xu WC, et al. Among authors: wright ge. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4197-202. doi: 10.1016/j.bmcl.2011.05.093. Epub 2011 May 30. Bioorg Med Chem Lett. 2011. PMID: 21684746 Free PMC article.

10

A novel agent effective against Clostridium difficile infection.

Dvoskin S, Xu WC, Brown NC, Yanachkov IB, Yanachkova M, Wright GE. Dvoskin S, et al. Among authors: wright ge. Antimicrob Agents Chemother. 2012 Mar;56(3):1624-6. doi: 10.1128/AAC.06097-11. Epub 2011 Dec 27. Antimicrob Agents Chemother. 2012. PMID: 22203600 Free PMC article.

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